Piflufolastat
Based on 1 Customer Validation
Piflufolastat (DCFPYL) can be used for the preparation of piflufolastat F 18 (DCFPyL F-18). Piflufolastat F-18 (DCFPyL F-18) is an 18F-labeled imaging agent. Piflufolastat F-18 can be used for positron emission tomography (PET) targeting prostate-specific membrane antigen (PSMA). Piflufolastat can be used for imaging of prostate cancer.
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- Pureté: 99.18%
- CAS No.: 1423758-00-2
- Formule: C18H23FN4O8
- Masse moléculaire:442.40
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Anti-Cancer Compound Library
HY-L025
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Anti-Prostate Cancer Compound Library
HY-L124
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Heterocyclic Compound Library
HY-L138
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
1.56 nM
Compound: 1; DCFPyL
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Inhibition of PSMA in human LNCaP cell extracts in presence of N-acetylaspartylglutamate by Amplex red glutamic acid dependent fluorescence-based NAALADase assay
Inhibition of PSMA in human LNCaP cell extracts in presence of N-acetylaspartylglutamate by Amplex red glutamic acid dependent fluorescence-based NAALADase assay
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[PMID: 32097010] |
Chemical Information
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CAS No. 1423758-00-2
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Appearance Solid
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Masse moléculaire 442.40
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Formule C18H23FN4O8
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Color White to off-white
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SMILES
O=C(CC[C@H](NC(N[C@@H](CCCCNC(C1=CC=C(N=C1)F)=O)C(O)=O)=O)C(O)=O)O
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Synonyms
DCFPYL
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 175 mg/mL (395.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Keam SJ, et al. Piflufolastat F 18: Diagnostic First Approval. Mol Diagn Ther. 2021;25(5):647-656. [Content Brief]
[2]. Chen Y, et al. 2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer. Clin Cancer Res. 2011;17(24):7645-7653. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2604 mL | 11.3020 mL | 22.6040 mL | 56.5099 mL |
| 5 mM | 0.4521 mL | 2.2604 mL | 4.5208 mL | 11.3020 mL | |
| 10 mM | 0.2260 mL | 1.1302 mL | 2.2604 mL | 5.6510 mL | |
| 15 mM | 0.1507 mL | 0.7535 mL | 1.5069 mL | 3.7673 mL | |
| 20 mM | 0.1130 mL | 0.5651 mL | 1.1302 mL | 2.8255 mL | |
| 25 mM | 0.0904 mL | 0.4521 mL | 0.9042 mL | 2.2604 mL | |
| 30 mM | 0.0753 mL | 0.3767 mL | 0.7535 mL | 1.8837 mL | |
| 40 mM | 0.0565 mL | 0.2825 mL | 0.5651 mL | 1.4127 mL | |
| 50 mM | 0.0452 mL | 0.2260 mL | 0.4521 mL | 1.1302 mL | |
| 60 mM | 0.0377 mL | 0.1884 mL | 0.3767 mL | 0.9418 mL | |
| 80 mM | 0.0283 mL | 0.1413 mL | 0.2825 mL | 0.7064 mL | |
| 100 mM | 0.0226 mL | 0.1130 mL | 0.2260 mL | 0.5651 mL |
Piflufolastat Related Classifications
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