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Cat. No.: HY-139008

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RC363

RC363 is a glutathione peroxidase 1 (GPx1) activator. RC363 enhances glutathione peroxidase activity and inhibits ferroptosis. RC363 can be used for the research of neurodegenerative conditions.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2584411-86-7
Formule: C₁₈H₂₄OS₂
Masse moléculaire:320.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

RC363 Chemical Structure

CAS No.: 2584411-86-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

GPX1

Voir tous les produits spécifiques à Isoform Glutathione Peroxidase :

GPX1
GPX4

In Vitro

RC363 (0.0625-3 μM; 1-48 h) inhibits glutamate-induced cytotoxicity in HT-22 cells^[1].
RC363 (3 μM; 6 h) does not significantly decrease oxidant levels in HT-22 cells^[1].
RC363 (3 μM; 24 h) significantly increases the protein level of GPx1 in HT-22 cells^[1].
RC363 (0.0625-1 μM; 24 h) inhibits RSL3 (HY-100218A)-induced ferroptosis in HT-22 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HT-22 cells, primary cortical neurons
Concentration:

3 μM
Incubation Time:

48 h
Result:

Exhibited no cytotoxicity to HT-22 cells.
Inhibited glutamate-induced ferroptosis.

Cell Viability Assay^[1]

Cell Line:

HT-22 cells
Concentration:

0.0625 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM
Incubation Time:

1 h; 2 h; 4 h; 6 h; 8 h
Result:

Exhibited fully protective at the concentration of ≥0.5 μM.
Presented significant protective effects when added simultaneously with glutamate. Gradually lost protection when the compound was added longer periods after the challenge.

Western Blot Analysis^[1]

Cell Line:

HT-22 cells
Concentration:

3 μM
Incubation Time:

24 h
Result:

Significantly increased the protein level of GPx1.

Chemical Information

CAS No. 2584411-86-7
Masse moléculaire 320.51
Formule C₁₈H₂₄OS₂
SMILES

OC1=C(C(C)(C)C)C=C(SC2=CC=CS2)C=C1C(C)(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Bueno DC, et al. New Probucol Analogues Inhibit Ferroptosis, Improve Mitochondrial Parameters, and Induce Glutathione Peroxidase in HT22 Cells. Mol Neurobiol. 2020;57(8):3273-3290. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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RC363

High-Throughput Bioactive Compound Library

Voir tous les produits spécifiques à Isoform Glutathione Peroxidase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

RC363 Related Classifications

HY-139008 Related Classifications