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Cat. No.: HY-115527

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SHP244

SHP244 is a conformational inhibitor targeting the "latch allosteric site" (site 2) of the SHP2 protein with an IC₅₀ value for SHP2^WT of 60 μM. SHP244 has no significant effect on the level of p-ERK alone. SHP244 combined with RMC-4550 (HY-116009) ("tunnel site" site 1 inhibitor) can reduce p-ERK and inhibit the rebound of p-ERK, thereby reducing drug resistance. SHP244 can be used to study drug resistance in FGFR-driven cancers.

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CAS No.: 902891-37-6
Formule: C₂₃H₁₇ClN₄O₃
Masse moléculaire:432.86

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

SHP244 Chemical Structure

CAS No.: 902891-37-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Chemical Information

CAS No. 902891-37-6
Masse moléculaire 432.86
Formule C₂₃H₁₇ClN₄O₃
SMILES

O=C1C2=C(N3C(C4=C(O)C(OC)=CC=C4)=NN=C3N1CC5=C(Cl)C=CC=C5)C=CC=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lu H, et al. Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR. Oncotarget. 2020 Jan 21;11(3):265-281.

[2]. Song Y, et al. Crystallographic landscape of SHP2 provides molecular insights for SHP2 targeted drug discovery. Medicinal Research Reviews. 2022 Sep;42(5):1781-821.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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