Sudemycin E
Sudemycin E is an analog of FR901464 (HY-16212). Sudemycin E can induce reversible changes in alternative splicing and abnormalities in chromatin modifications by binding to SF3B1, a component of the U2 small nuclear ribonucleoprotein (snRNP), thereby leading to the death of cancer cells. Sudemycin E has anti-tumor activity and can be used in tumor research.
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- CAS No.: 1197054-49-1
- Formule: C27H41NO7
- Masse moléculaire:491.62
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| JeKo-1 | IC50 |
150 nM
Compound: 26
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Cytotoxicity against human JeKo1 cells after 72 hrs by XTT assay
Cytotoxicity against human JeKo1 cells after 72 hrs by XTT assay
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[PMID: 19877647] |
| JeKo-1 | IC50 |
220 nM
Compound: 19p
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Cytotoxicity against human JeKo1 cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human JeKo1 cells after 72 hrs by CellTiter-Glo assay
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[PMID: 24325474] |
Chemical Information
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CAS No. 1197054-49-1
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Masse moléculaire 491.62
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Formule C27H41NO7
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SMILES
CC(C)C(O[C@@H](C)/C=C\C(N[C@@H](CO1)CO[C@@H]1C/C=C(C)/C=C/[C@@H]2C[C@@]3(CC(C)(O2)C)CO3)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sudemycin E Related Classifications
HY-120907 Related Classifications
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