Chlorphenesin carbamate
Based on 1 Customer Validation
Chlorphenesin carbamate is a centrally acting skeletal muscle relaxant, as well as a derivate of Chlorphenesin (HY-A0133). Chlorphenesin carbamate can be used for the research of pain and discomfort related to skeletal muscle trauma and inflammation. Chlorphenesin carbamate is a selective blocker of polysynaptic pathways at the spinal and supra-spinal levels. Antinociceptive effect.
For research use only. We do not sell to patients.
- Purity: 99.12%
- CAS No.: 886-74-8
- Formula: C10H12ClNO4
- Molecular Weight:245.66
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chlorphenesin carbamate (CPC) has an antinociceptive action in adjuvant arthritic rats. Chlorphenesin carbamate (100-400 mg/kg, p.o.) has a dose-dependent antinociceptive effect in the behavioral study. Chlorphenesin carbamate (25-50 mg/kg, i.v.) depresses the evoked neuronal responses of nociceptive neurons in the ventrobasal thalamus (VB) in the electrophysiological study. Chlorphenesin carbamate (50 mg/kg, i.v.) depresses the spontaneous firings of the VB nociceptive neurons[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wister rats weighing 200-300 g[3]
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Dosage:50 mg/kg
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Administration:Intravenously administered
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Result:Significantly inhibited PSR, with the maximum inhibition at 40 min after the drug administration.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 886-74-8
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Appearance Solid
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Molecular Weight 245.66
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Formula C10H12ClNO4
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Color White to off-white
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SMILES
OC(COC1=CC=C(Cl)C=C1)COC(N)=O
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Synonyms
Maolate; U 19646
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 125 mg/mL (508.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Ji-young Yu, et al. Relative bioavailability of generic and branded 250-mg and 500-mg oral chlorphenesin carbamate tablets in healthy Korean volunteers: a single-dose, randomized-sequence, open-label, two-period crossover trial. Clin Ther. 2009 Nov;31(11):2735-43. [Content Brief]
[2]. M Kurachi, et al. Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats. Jpn J Pharmacol. 1984 Sep;36(1):7-13. [Content Brief]
[3]. S Okuyama, et al. Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats. Res Commun Chem Pathol Pharmacol. 1987 Feb;55(2):147-60. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0707 mL | 20.3533 mL | 40.7067 mL | 101.7667 mL |
| 5 mM | 0.8141 mL | 4.0707 mL | 8.1413 mL | 20.3533 mL | |
| 10 mM | 0.4071 mL | 2.0353 mL | 4.0707 mL | 10.1767 mL | |
| 15 mM | 0.2714 mL | 1.3569 mL | 2.7138 mL | 6.7844 mL | |
| 20 mM | 0.2035 mL | 1.0177 mL | 2.0353 mL | 5.0883 mL | |
| 25 mM | 0.1628 mL | 0.8141 mL | 1.6283 mL | 4.0707 mL | |
| 30 mM | 0.1357 mL | 0.6784 mL | 1.3569 mL | 3.3922 mL | |
| 40 mM | 0.1018 mL | 0.5088 mL | 1.0177 mL | 2.5442 mL | |
| 50 mM | 0.0814 mL | 0.4071 mL | 0.8141 mL | 2.0353 mL | |
| 60 mM | 0.0678 mL | 0.3392 mL | 0.6784 mL | 1.6961 mL | |
| 80 mM | 0.0509 mL | 0.2544 mL | 0.5088 mL | 1.2721 mL | |
| 100 mM | 0.0407 mL | 0.2035 mL | 0.4071 mL | 1.0177 mL |
Chlorphenesin carbamate Related Classifications
HY-107944 Related Classifications
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