Alkynes

WyneO is a probe for the detection of sulfenylated proteins.

Longanlactone is a natural pyrrole-lactone alkaloid that can be used as a neurotrophic agent. Longanlactone increases BDNF gene expression in neuro2a cells.

Ethyne-C2-Pip-CO-Pip-Boc (Compound 21) is a PROTAC linker. Ethyne-C2-Pip-CO-Pip-Boc can be used to synthesize QA-68 (HY-150797).

Antifungal agent 119 (compund T23) is an antifungal agent that targets type I reduced NADH oxidoreductase. Antifungal agent 119 carries an azide group and can be used for click chemistry reactions..

BB-F-Yne is a protein arginine deiminase (PAD) inhibitor with K_i values of PAD1-4.are 2050, 1700, 1100, 3100 M^-1min^-1 respectively. BB-F-Yne can be used as a click probe to label PAD.

Dinordrin (Dinordrin I) is a steroid with a luteolytic effect. Dinordrin can cause depression of both plasma estrogen and progesterone levels.

L-767679 (compound I) is a hydrophilic zwitterion with a low intestinal metabolism.

Golexanolone is a GABA_A receptor modulating steroid antagonist. Golexanolone reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in hyperammonemic rats.

CB30900 is an inhibitor for thymidylate synthase with an IC₅₀ of 0.2 μM. CB30900 exhibits cytotoxicity in W1L2 with an IC₅₀ of 0.13 μM.

FAM alkyne, 6-isomer is a click chemistry regent that can be used in 1,3-dipolar cycloaddition with azido-labeled compound.

Sulfo-cyanine7 alkyne is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.

Sulfo-cyanine7 alkyne potassium is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.

Bodipy TR alkyneis one of a boron dipyrromethene fluorophore for the ROX (Texas Red) channel. This is a versatile fluorophore that can be used in microscopy, fluorescence polarization measurements, and other applications. This derivative is a terminal alkyne of copper-catalyzed click chemistry.

5-ROX-alkyne is a rhodamine dye that labels DNA fragments. It enables visualization of the results of capillary electrophoresis genotyping experiments and gel shift experiments.

Cy3.5 alkyne, a fluorescent dye, is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Cy3.5 alkyne can be used for the detection and labeling of azide-containing molecules/ biomolecules with fluorescence spectroscopy after azide-alkyne cycloaddition.

H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported. H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Fmoc-D-Lys(pentynoyl)-OH is a click chemistry reagent containing an azide group. Used to introduce alkyne functionality into peptides that can be further modified using Click-chemistry.

Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in peptide synthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported. Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Fmoc-L-Dap(Poc)-OH is a click chemistry reagent containing an azide group. Amino acid building block suitable for side chain Click conjugation with standard protocols and together with tetrazine linkers in copper-free Click conjugation (Diels-Alder).

DecarboxyBiotin-Alkyne is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity.