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  3. QA-68

QA-68 (Synonyms: QA-68-ZU81)

Cat. No.: HY-150797
Handling Instructions

QA-68 (QA-68-ZU81) is a potent bromodomain-containing protein 9 (BRD9) degrader. QA-68 can inhibit cell cycle progression and cell colony formation. QA-68 has antiproliferative activity against acute myeloid leukemia (AML) cell lines.

For research use only. We do not sell to patients.

QA-68 Chemical Structure

QA-68 Chemical Structure

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Description

QA-68 (QA-68-ZU81) is a potent bromodomain-containing protein 9 (BRD9) degrader. QA-68 can inhibit cell cycle progression and cell colony formation. QA-68 has antiproliferative activity against acute myeloid leukemia (AML) cell lines[1].

IC50 & Target[1]

BRD9

 

In Vitro

QA-68 (0-1000 nM; 24 h) exhibits antiproliferative activity against MV4-11, SKM-1 and Kasumi-1-luc+ cells, and inhibits BRD9 protein expression in MV4-11, SKM-1, SEM, NALM6, RS4;11[1].
QA-68 (0.1-1000 nM; 4 days) effectively inhibits SKM-1 cell cycle progression[1].
QA-68 (1000 nM; 12 days) inhibits colony formation of additional primary AML bone marrow and PBMC cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MV4-11, SKM-1 and Kasumi-1-luc+ cells
Concentration: 0-1000 nM
Incubation Time: 24 h
Result: Exhibited concentration-dependent inhibition of proliferation of MV4-11, SKM-1 and Kasumi-1-luc+ cells with IC50s of 1-10 nM in MV4;11 and SKM-1, and IC50 of 10-100 nM in Kasumi-1-luc +, respectively.

Cell Cycle Analysis[1]

Cell Line: SKM-1cells
Concentration: 0.1, 1, 10, 100 and 1000 nM
Incubation Time: 6 days
Result: Effectively inhibited SKM-1 cell cycle progression.

Western Blot Analysis[1]

Cell Line: MV4-11, SKM-1, SEM, NALM6, RS4;11
Concentration: 0, 1, 10, 100 and 1000 nM
Incubation Time: 24 h
Result: Inhibited BRD9 protein in all tested cell lines.
Molecular Weight

1169.42

Formula

C61H72N10O10S2

SMILES

CCCN1C=C(C2=C(C1=O)C=C(C(NC3CCS(CC3)(=O)=O)=O)S2)C4=CC=C(C5=C4)N(C=C5C)CC6CCN(CC6)C(CCC(N7CCN(CC7)C(N8CCN(CC8)CCC#CC9=CC=CC%10=C9CN(C%10=O)C%11CCC(NC%11=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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QA-68
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HY-150797
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