COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP) 

COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) is an mRNA encoding the SARS-CoV-2 spike protein with enhanced performance via chemical modification. COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) replaces natural uridine (UTP) with N1-Me-Pseudo UTP, which effectively reduces immunogenicity and improves stability and translation efficiency. The 3' UTR of COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) optimizes AU-rich elements through HuR anchor sites, exhibiting higher translation efficiency. COVID-19 Spike Protein mRNA is widely used in COVID-19-related scientific research and vaccine development^[1][2][3][4].

COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) not only contains N1-Me-Pseudo UTP modification, but also mimics the complete structure of natural mRNA, including the 5' Cap 1 cap structure, 5' and 3' untranslated regions (UTR), and 3' poly (A) tail, ensuring efficient expression of the spike protein in human cells. After injection into the human body, COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) directs cells to produce the spike protein, thereby safely training the immune system to recognize and attack the authentic SARS-CoV-2 virus, providing strong protection against COVID-19^[1].
COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) has three key advantages: significantly reduced immunogenicity (avoiding excessive recognition by the human immune system), enhanced molecular stability (prolonging its half-life in vivo), and improved translation efficiency (producing more spike proteins to trigger immune responses)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Liquid

Colorless to light yellow

[COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)]

Shipping with dry ice.

-80°C

• [1]. Zhang Y, et al. Lung-Selective Delivery of mRNA-Encoding Anti-MERS-CoV Nanobody Exhibits Neutralizing Activity Both In Vitro and In Vivo. Vaccines (Basel). 2024;12(12):1315. Published 2024 Nov 24.  [Content Brief]

  [2]. Ma X, et al. Enhancing mRNA translation efficiency by introducing sequence optimized AU-rich elements in 3' UTR via HuR anchorage. Mol Ther Nucleic Acids. 2025;36(2):102485. Published 2025 Feb 12.  [Content Brief]

  [3]. Li M, et al. An mRNA vaccine against rabies provides strong and durable protection in mice. Front Immunol. 2023;14:1288879. Published 2023 Oct 26.  [Content Brief]

  [4]. Cheng X, et al. A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges. Adv Mater. 2024;36(13):e2310886.  [Content Brief]