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Cat. No.: HY-153083

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COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)

Name: COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)
Brand: MedChemExpress
SKU: HY-153083
Price: 280.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) is an mRNA encoding the SARS-CoV-2 spike protein with enhanced performance via chemical modification. COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) replaces natural uridine (UTP) with N1-Me-Pseudo UTP, which effectively reduces immunogenicity and improves stability and translation efficiency. The 3' UTR of COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) optimizes AU-rich elements through HuR anchor sites, exhibiting higher translation efficiency. COVID-19 Spike Protein mRNA is widely used in COVID-19-related scientific research and vaccine development.

For research use only. We do not sell to patients.

Purity : 89%

Storage:

-80°C

COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP) Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) not only contains N1-Me-Pseudo UTP modification, but also mimics the complete structure of natural mRNA, including the 5' Cap 1 cap structure, 5' and 3' untranslated regions (UTR), and 3' poly (A) tail, ensuring efficient expression of the spike protein in human cells. After injection into the human body, COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) directs cells to produce the spike protein, thereby safely training the immune system to recognize and attack the authentic SARS-CoV-2 virus, providing strong protection against COVID-19^[1].
COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) has three key advantages: significantly reduced immunogenicity (avoiding excessive recognition by the human immune system), enhanced molecular stability (prolonging its half-life in vivo), and improved translation efficiency (producing more spike proteins to trigger immune responses)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Appearance Liquid
Color Colorless to light yellow
SMILES

[COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)]
Shipping

Shipping with dry ice.
Storage

-80°C

Publications (1)

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Journal Impact Factor

Trends Biotechnol

Extended human lymph node explants for evaluation of adaptive immunity. [Abstract]

2025 Aug 29:S0167-7799(25)00302-6. PMID: 40885665

Protocols

All Molecular Biology

RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Lung-Selective Delivery of mRNA-Encoding Anti-MERS-CoV Nanobody Exhibits Neutralizing Activity Both In Vitro and In Vivo. Vaccines (Basel). 2024;12(12):1315. Published 2024 Nov 24. [Content Brief]

[2]. Ma X, et al. Enhancing mRNA translation efficiency by introducing sequence optimized AU-rich elements in 3' UTR via HuR anchorage. Mol Ther Nucleic Acids. 2025;36(2):102485. Published 2025 Feb 12. [Content Brief]

[3]. Li M, et al. An mRNA vaccine against rabies provides strong and durable protection in mice. Front Immunol. 2023;14:1288879. Published 2023 Oct 26. [Content Brief]

[4]. Cheng X, et al. A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges. Adv Mater. 2024;36(13):e2310886. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)

1 Cited Publications

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Protocols
Purity & Documentation
References

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COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)

Publications Citing Use of MedChemExpress (MCE) COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)