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CP-100356

9 Cited Publications
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Based on 9 publication(s) in Google Scholar

CP-100356 is an orally active dual MDR1 (P-gp)/BCRP inhibitor, with an IC50s of 0.5 and 1.5 µM for inhibiting MDR1-mediated Calcein-AM transport and BCRP-mediated Prazosin transport, respectively. CP-100356 is also a weak inhibitor of OATP1B1 (IC50 = ∼66 µM). CP-100356 is devoid of inhibition against MRP2 and major human P450 enzymes (IC50 > 15 µM).

For research use only. We do not sell to patients.

  • CAS No.: 142716-85-6
  • Formula: C31H36N4O6
  • Molecular Weight:560.64
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • CP-100356 Chemical Structure
    CP-100356 Chemical Structure
  • Experimental Validation Results for CP-100356
  • Experimental Validation Results for CP-100356
  • Experimental Validation Results for CP-100356
  • Experimental Validation Results for CP-100356
  • Experimental Validation Results for CP-100356
CAS No.: 142716-85-6
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[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Publications Citing Use of MedChemExpress (MCE) CP-100356

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  • Cell Proliferation/Viability Assay
  • Bio/Physico-chemical Assay
  • Cell Proliferation/Viability Assay

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  • CP-100356 Chemical Structure
    CP-100356 Chemical Structure
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  • 1/16

    CP-100356 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 3.

    Customer Validation
     CP-100356 hydrochloride (0.5-1.5 μM; 72 h) increased FT235 antiviral activity against the ancestral B.1 86 strain.

  • 1/16

    CP-100356 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 3.

    Customer Validation
     CP-100356 hydrochloride (0.5, 1, 1.5 μM; 72 h) increased FT235 antiviral activity against SARS-CoV-2 141 B.1 variant.

  • 1/16

    CP-100356 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 3.

    Customer Validation
     CP-100356 hydrochloride (0.5 μM; 72 h) showed no measurable activity against the Omicron BA.5 variant.

  • 1/16

    CP-100356 purchased from MedChemExpress. Usage Cited in: SLAS Discov. 2024 Jul;29(5):100160. [Abstract]

    Customer Validation
     CP-100356 hydrochloride (EI; 1 μM) showed CPE inhibition with an IC50 of 0.047 μM when combined with PF-07321332 in Vero E6 cells with enhanced ACE-2 expression infected with the WA1/2020 isolate of SARS-CoV-2.

  • 1/16

    CP-100356 purchased from MedChemExpress. Usage Cited in: SLAS Discov. 2024 Jul;29(5):100160. [Abstract]

    Customer Validation
     CP-100356 hydrochloride (0-100 μM) showed cytotoxic activity with a CC50 value of 6.81 μM for Vero E6 cells.

  • CP-100356