CRBN ligand-774
Based on 1 Customer Validation
CRBN ligand-774 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-774 can be linked to a target protein ligand via a linker to form a PROTAC.
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- CAS No.: 2888604-15-5
- Formule: C18H23ClN4O2
- Masse moléculaire:362.86
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Stockage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
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Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2888604-15-5
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Appearance Solid
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Masse moléculaire 362.86
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Formule C18H23ClN4O2
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Color White to off-white
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SMILES
Cl.O=C1NC(=O)C(C2=NN(C=3C=C(C=CC32)C4CCNCC4)C)CC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvant et solubilité
In Vitro:
DMSO : 4 mg/mL (11.02 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (246 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7559 mL | 13.7794 mL | 27.5588 mL | 68.8971 mL |
| 5 mM | 0.5512 mL | 2.7559 mL | 5.5118 mL | 13.7794 mL | |
| 10 mM | 0.2756 mL | 1.3779 mL | 2.7559 mL | 6.8897 mL |
CRBN ligand-774 Related Classifications
HY-W883939 Related Classifications
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