2. PROTAC
  3. Ligands for E3 Ligase
  4. CRBN ligand-774

CRBN ligand-774 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-774 can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-774

CRBN ligand-774 Chemical Structure

CAS No. : 2888604-15-5

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CRBN ligand-774 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

CRBN ligand-774 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-774 can be linked to a target protein ligand via a linker to form a PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CRBN ligand-774 Related Antibodies
Molecular Weight

362.86

Formula

C18H23ClN4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

Cl.O=C1NC(=O)C(C2=NN(C=3C=C(C=CC32)C4CCNCC4)C)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
Solvent & Solubility
In Vitro: 

DMSO : 4 mg/mL (11.02 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7559 mL 13.7794 mL 27.5588 mL
5 mM 0.5512 mL 2.7559 mL 5.5118 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7559 mL 13.7794 mL 27.5588 mL 68.8971 mL
5 mM 0.5512 mL 2.7559 mL 5.5118 mL 13.7794 mL
10 mM 0.2756 mL 1.3779 mL 2.7559 mL 6.8897 mL
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CRBN ligand-774 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-7742888604-15-5CRBN ligand774CRBN ligand 774Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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