Cyclopropavir  (Synonyms: Filociclovir; ZSM-I-62; MBX-400)

Cyclopropavir (Filociclovir) is an orally active and broad-spectrum anti-herpesvirus compound. Cyclopropavir inhibits UL97 kinase activity. Cyclopropavir has antiviral activity against HCMV, MCMV, and HAdV6 viruses^{[1][2][3][4][5]}.

Cyclopropavir exhibits antiviral activity against HCMV in human foreskin fibroblasts (HFFs) and mouse embryo fibroblasts (MEFs)^[1].
Cyclopropavir (15 µM) inhibits UL97 kinase activity in COS7 cells transfected with UL97 and pp65-GFP fusion protein, as shown by increased formation of nuclear aggresomes^[2].
Cyclopropavir (2.5 µM; 5 days) achieves a shorter half-life compared to Ganciclovir (HY-13637) in HCMV-infected human foreskin fibroblasts (HFFs)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclopropavir (1-10 mg/kg; p.o.; 5-28 days) reduces mortality and viral titers in BALB/c mice and SCID mice infected with MCMV^[4].
Cyclopropavir (10-30 mg/kg; p.o.) prevents mortality, mitigates liver/lung pathology, and reduces viral replication in immunosuppressed Syrian hamsters infected intravenously or intranasally with HAdV6^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

263.26

C₁₁H₁₃N₅O₃

632325-71-4

Solid

White to off-white

OCC(/C1=C/N2C3=C(C(N=C(N)N3)=O)N=C2)(C1)CO

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Kern ER, et al. In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication. Antimicrob Agents Chemother. 2005 Mar;49(3):1039-45.  [Content Brief]

  [2]. James SH, et al. Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase. Antimicrob Agents Chemother. 2011 Oct;55(10):4682-91.  [Content Brief]

  [3]. Gentry BG, et al. Metabolism of cyclopropavir and ganciclovir in human cytomegalovirus-infected cells. Antimicrob Agents Chemother. 2014;58(4):2329-33.  [Content Brief]

  [4]. Kern ER, et al. Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections. Antimicrob Agents Chemother. 2004 Dec;48(12):4745-53.  [Content Brief]

  [5]. Toth K, et al. Filociclovir Is a Potent In Vitro and In Vivo Inhibitor of Human Adenoviruses. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01299-20.  [Content Brief]