D-(-)-3-Phosphoglyceric acid disodium
Based on 1 publication(s) in Google Scholar
D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalyzed glycolysis process. D-(-)-3-Phosphoglyceric acid disodium competitively inhibits yeast enolase (enolase). D-(-)-3-Phosphoglyceric acid disodium can regulate the activity of phosphoglycerate dehydrogenase (PHGDH) to modulate p53 protein and apoptosis.
For research use only. We do not sell to patients.
- Purity: 99.43%
- CAS No.: 80731-10-8
- Formula: C3H5Na2O7P
- Molecular Weight:230.02
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) D-(-)-3-Phosphoglyceric acid disodium
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Biological Activity
D-(-)-3-Phosphoglyceric acid disodium (low level) induces phosphorylation at the Ser46 site of p53[1].
D-(-)-3-Phosphoglyceric acid disodium (high level) binding PHGDH mutants (R135W and V261M) impair p53 activation[1].
D-(-)-3-Phosphoglyceric acid disodium (high level) binding to the PHGDH-R135W and PHGDH-V261M mutants blocks apoptosis induced by 8 hours of glucose starvation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 80731-10-8
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Appearance Solid
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Molecular Weight 230.02
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Formula C3H5Na2O7P
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Color White to off-white
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SMILES
O=C(O[Na])[C@H](O)COP(O)(O[Na])=O
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Synonyms
3-Phospho-D-glyceric acid disodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
H2O : 100 mg/mL (434.74 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
[1]. Yu-Qing Wu, et al. Low glucose metabolite 3-phosphoglycerate switches PHGDH. Cell Res. 2023 Nov;33(11):835-850. [Content Brief]
[2]. Ramos ML, Justino LL, Gil VM, Burrows HD. NMR and DFT studies of the complexation of W(VI) and Mo(VI) with 3-phospho-D-glyceric and 2-phospho-D-glyceric acids. Dalton Trans. 2009;(43):9616-9624. [Content Brief]
[3]. Faller LD, et al. Calorimetric studies of the role of magnesium ions in yeast enolase catalysis. Proc Natl Acad Sci U S A. 1974;71(4):1083-1087. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.3474 mL | 21.7372 mL | 43.4745 mL | 108.6862 mL |
| 5 mM | 0.8695 mL | 4.3474 mL | 8.6949 mL | 21.7372 mL | |
| 10 mM | 0.4347 mL | 2.1737 mL | 4.3474 mL | 10.8686 mL | |
| 15 mM | 0.2898 mL | 1.4491 mL | 2.8983 mL | 7.2457 mL | |
| 20 mM | 0.2174 mL | 1.0869 mL | 2.1737 mL | 5.4343 mL | |
| 25 mM | 0.1739 mL | 0.8695 mL | 1.7390 mL | 4.3474 mL | |
| 30 mM | 0.1449 mL | 0.7246 mL | 1.4491 mL | 3.6229 mL | |
| 40 mM | 0.1087 mL | 0.5434 mL | 1.0869 mL | 2.7172 mL | |
| 50 mM | 0.0869 mL | 0.4347 mL | 0.8695 mL | 2.1737 mL | |
| 60 mM | 0.0725 mL | 0.3623 mL | 0.7246 mL | 1.8114 mL | |
| 80 mM | 0.0543 mL | 0.2717 mL | 0.5434 mL | 1.3586 mL | |
| 100 mM | 0.0435 mL | 0.2174 mL | 0.4347 mL | 1.0869 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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