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Art. -Nr.: HY-144361

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Antitumor agent-44

Antitumor agent-44 (Compound 5n) disrupts the mitochondrial homeostasis, induces cell cycle arrest and apoptosis in human adenocarcinoma cells. Antitumor agent-44 (Compound 5n) possesses good anti-tumor activity in a lung-cancer-cell xenograft mice model.

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CAS. Nr.: 1811548-74-9
Formel: C₂₄H₁₅N₃O₃
Molecular Weight:393.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Antitumor agent-44 Chemical Structure

CAS. Nr.: 1811548-74-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.82 μM Compound: 5n	Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 35219149]
NRK-52E	IC₅₀	1.25 μM Compound: 5n	Antiproliferative activity against rat NRK-52E cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against rat NRK-52E cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 35219149]

Chemical Information

CAS. Nr. 1811548-74-9
Molecular Weight 393.39
Formel C₂₄H₁₅N₃O₃
SMILES

O=C(C1=CC=C(OCO2)C2=C1)C3=CC=CC4=C3N(C5=NC=CC=N5)C6=C4C=CC=C6
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xiao-Xuan Su, et al. Design, synthesis, and evaluation of 9-(pyrimidin-2-yl)-9H-carbazole derivatives disrupting mitochondrial homeostasis in human lung adenocarcinoma. Eur J Med Chem. 2022 Mar 15;232:114200. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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