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Art. -Nr.: HY-N11536

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erythro-Austrobailignan-6

erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK.

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CAS. Nr.: 114127-24-1
Formel: C₂₀H₂₄O₄
Molecular Weight:328.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

erythro-Austrobailignan-6 Chemical Structure

CAS. Nr.: 114127-24-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Topoisomerase Isoform-spezifische Produkte anzeigen :

In Vitro

erythro-Austrobailignan-6 (100 μM) inhibits DNA topoisomerase I more than 50%^[1].
erythro-Austrobailignan-6 (0-30 μM, 24 or 48 h) inhibits the proliferation of 4T-1 cells and MCF-7 cells^[1].
erythro-Austrobailignan-6 (2-30 μM, 24 or 48 h) induces apoptosis in 4T-1 and MCF-7 cells^[1].
erythro-Austrobailignan-6 (10 μM, 30-120 min) increases phosphorylation of p38 and JNK in 4T-1 and MCF-7 cells^[1].
erythro-Austrobailignan-6 (5 and 10 μM, 24 h) decreases EGFR/HER2 and topoisomerase in 4T-1 and MCF-7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

4T-1 and MCF-7 cells
Concentration:

0-30 μM
Incubation Time:

24 or 48 h
Result:

Dose dependently inhibited cell proliferation.

Western Blot Analysis^[1]

Cell Line:

4T-1 and MCF-7 cells
Concentration:

100 μM
Incubation Time:

30, 60 or 120 min
Result:

Increased phosphorylation of p38 and JNK.
Activated caspase-3 and inhibited CDK-4 and cyclin D1.

In Vivo

erythro-Austrobailignan-6 (food intake, for 20 days) inhibits tumor growth in 4T-1 tumor bearing mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

4T-1 tumor bearing mice^[1]
Dosage:

20 mg/kg/day
Administration:

Food intake
Result:

Inhibited tumor growth by 40.8%;
Down-regulated CDK-4, cyclin D1, HER2 and integrin β3;
Up-regulated cleaved caspase-3 in tumor.

Chemical Information

CAS. Nr. 114127-24-1
Molecular Weight 328.40
Formel C₂₀H₂₄O₄
SMILES

COC(C=C1C[C@@H](C)[C@@H](C)CC2=CC=C(OCO3)C3=C2)=C(C=C1)O
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Han JH, et al. Erythro-austrobailignan-6 down-regulates HER2/EGFR/integrinβ3 expression via p38 activation in breast cancer. Phytomedicine. 2017 Jan 15;24:24-30. [Content Brief]

[2]. Lee YK, et al. Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis. Arch Pharm Res. 2009 Oct;32(10):1409-15. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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