HCVcc-IN-2
HCVcc-IN-2 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor and antiviral activity. HCVcc-IN-2 has high inhibition against the three cell line from CNS cancer (SF-539 and SNB-75), colon cancer (HCT-116), and renal cancer (A498).
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- CAS. Nr.: 2977251-02-6
- Formel: C32H29BrN2O10S3
- Molecular Weight:777.68
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
HCVcc-IN-2 (compound 6c) (0.1, 1, 10, and 100 μg/mL; 1 h) shows antiviral activities against a variety of viruses such as coxsackievirus B4 (CBV4), hepatitis A virus HM 175 (HAV), hepatitis C genotype 4 (HCVcc), adenovirus type 7 (HAdV7), and herpes simplex virus 1 (HSV-1) with viral reduction rates of 83.3%, 63.3%, 40%, 63.3%, and 30%, respectively[1].
HCVcc-IN-2 (0.55-1.9 μg/mL; 1 h) inhibits various virus with IC50 of 0.55 μg/mL (herpes simplex virus), 0.76 μg/mL (HCVcc genotype virus), and 0.76 μg/mL (coxsackievirus B4), respectively; or with CC50 of 1.8 μg/mL (herpes simplex virus), 1.9 μg/mL (HCVcc genotype virus), and 1.9 μg/mL (coxsackievirus B4), respectively[1].
HCVcc-IN-2 (7.68-16.01 μg/mL; ) inhibits hepatitis C virus NS3/4A and HSV- USP7 protease enzyme with IC50s of 16.01 μg/mL and 7.68 μg/mL[1].
HCVcc-IN-2 (0.01 mM; 24 h) has low cytotoxicity, shows high inhibition against two cell lines, SK-MEL-5, OVCAR-4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:FRHK-4, Hep2, BGM, Vero, and Huh 7.5 cell lines
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Concentration:100 μg/mL
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Incubation Time:24 hours
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Result:Showed nontoxic under the doses of 100 μg/mL against FRHK-4, Hep2, BGM, Vero, and Huh 7.5 cells, respectively.
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Cell Line:SF-539, SNB-75, HCT-116, and A498
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Concentration:0.01 mM
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Incubation Time:24 hours
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Result:Inhibited SF-539, SNB-75, HCT-116, and A498 cell viability by 15.70%, 16.66%, 75.89%, and 58.5%, respectively.
Chemical Information
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CAS. Nr. 2977251-02-6
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Molecular Weight 777.68
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Formel C32H29BrN2O10S3
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SMILES
O=C(C1=C(N)C(C2=NC3=CC=CC=C3S2)=C(S[C@H]4[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@](OC(C)=O)([H])[C@@H](COC(C)=O)O4)S1)C5=CC=C(Br)C=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HCVcc-IN-2 Related Classifications
HY-151589 Related Classifications
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