Ligand binding mode of GABAA receptor-associated protein

  • J Mol Biol. 2008 Sep 19;381(5):1320-31. doi: 10.1016/j.jmb.2008.06.086.
Oliver H Weiergräber  1 ,  Thomas Stangler ,  Yvonne Thielmann ,  Jeannine Mohrlüder ,  Katja Wiesehan ,  Dieter Willbold
Affiliations
  • 1. Institut für Neurowissenschaften und Biophysik, Molekulare Biophysik, Forschungszentrum Jülich, D-52425 Jülich, Germany.
PMID: 18638487 DOI: 10.1016/j.jmb.2008.06.086
Abstract

The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray structure of the soluble form of human GABA(A) receptor-associated protein complexed with a high-affinity synthetic peptide at 1.3 A resolution. The data shed light on the probable binding modes of key interaction partners, including the GABA(A) receptor and the cysteine protease Atg4. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.

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