Synthesis and biological evaluation of 1,3,5-triazine and 2-aminopyrimidine scaffolds as chemical probes targeting the 5-HT7-FOXM1 axis in triple-negative breast cancer

  • Eur J Med Chem. 2026 May 5:309:118776. doi: 10.1016/j.ejmech.2026.118776.
Damian Kułaga  1 ,  Aleksandra Strzykalska-Augustyniak  2 ,  Michalina Gos  3 ,  Anna K Drabczyk  4 ,  Przemysław Zaręba  5 ,  Katarzyna Malarz  6 ,  Kinga Szafran-Pilch  7 ,  Modesto de Candiae  8 ,  Caterina Deruvog  8 ,  Beata Filip-Psurska  2 ,  Katarzyna Greber  9 ,  Krzesimir Ciura  10
Affiliations
  • 1. Department of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, Cracow, 31-155, Poland. Electronic address: [email protected].
  • 2. Polish Academy of Sciences, Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Experimental Anticancer Therapy, Wrocław, Poland.
  • 3. Polish Academy of Sciences, Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Biomedical Chemistry, Wrocław, Poland.
  • 4. Department of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, Cracow, 31-155, Poland.
  • 5. Department of Chemical Technology and Environmental Analytics, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, Cracow, 31-155, Poland.
  • 6. Institute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, Chorzów, 41-500, Poland.
  • 7. Maj Institute of Pharmacology, Polish Academy of Sciences, Centre for the Development of Novel Pharmacotherapies for CNS Disorders (Cephares), 12 Smętna Street, Cracow, 31-343, Poland.
  • 8. University of Bari "Aldo Moro", Department of Pharmacy-Pharmaceutical Sciences, 4 E. Orabona Street, Bari, I-70125, Italy.
  • 9. Department of Physical Chemistry, Faculty of Chemistry, Medical University of Gdańsk, 107 Gen. Hallera Alley, Gdańsk, 80-416, Poland.
  • 10. Department of Physical Chemistry, Faculty of Chemistry, Medical University of Gdańsk, 107 Gen. Hallera Alley, Gdańsk, 80-416, Poland; Laboratory of Environmental Chemoinformatics, Faculty of Chemistry, University of Gdansk, 63 Wita Stwosza Street, Gdansk, 80-308, Poland.
PMID: 41844115 DOI: 10.1016/j.ejmech.2026.118776
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