country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Fgr - FGR proto-oncogene, Src family tyrosine kinase Gene

Also Known as Ali18; Mhdaali18

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14191

Summary

Enables several functions, including immunoglobulin receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including defense response to Gram-positive bacterium; integrin-mediated signaling pathway; and regulation of vesicle-mediated transport. Acts upstream of or within bone mineralization and skeletal system morphogenesis. Located in plasma membrane. Colocalizes with actin Cytoskeleton and ruffle membrane. Is expressed in 2-cell stage embryo; blastocyst; nervous system; and neural ectoderm. Orthologous to human FGR (FGR proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Fgr Products (1)

mRNA	Protein	Name
NM_010208.4	NP_034338.3	tyrosine-protein kinase Fgr

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables immunoglobulin receptor binding	IDA IDA: Inferred from direct assay	21746961	MGI
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	15561106	MGI
enables phosphotyrosine residue binding	IDA IDA: Inferred from direct assay	11672534	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16439675	MGI
enables protein kinase binding	IDA IDA: Inferred from direct assay	11672534	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11672534	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	16964445	MGI
acts upstream of or within defense response to Gram-positive bacterium	IGI IGI: Inferred from genetic interaction	8125254	MGI
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	8125254	MGI
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11672534	MGI
involved in negative regulation of natural killer cell activation	IMP IMP: Inferred from mutant phenotype	16439675	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	15561106	MGI
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	15561106	MGI
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	21746961	MGI
involved in positive regulation of mast cell degranulation	IDA IDA: Inferred from direct assay	21746961	MGI
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	11672534	MGI
involved in regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	21746961	MGI
involved in regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	11672534	MGI
involved in regulation of protein kinase activity	IDA IDA: Inferred from direct assay	11672534	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	16964445	MGI

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with actin cytoskeleton	IDA IDA: Inferred from direct assay	15561106	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15561106	MGI
colocalizes with ruffle membrane	IDA IDA: Inferred from direct assay	15561106	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tyrosine-protein kinase Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog p55-Fgr proto-oncogene c-Fgr proto-oncogene tyrosine-protein kinase Fgr

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-178014	SIK1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgr	NCBI	NCBI:2268