GNAI1 - G protein subunit alpha i1 Gene

Also Known as Gi; HG1B; NEDHISB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2770

About GNAI1

Cytogenetic location: 7q21.11 Genomic coordinates (GRCh38): 7:80,134,831-80,226,181 (from NCBI)

This gene has 32 transcripts (splice variants), 224 orthologues, 15 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 39.3), brain (RPKM 28.1) and 22 other tissues.

Summary

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with Other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting Adenylate Cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GNAI1 Products (2)

mRNA	Protein	Name
NM_001256414.2	NP_001243343.1	guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 2
NM_002069.6	NP_002060.4	guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables D2 dopamine receptor binding	IPI IPI: Inferred from physical interaction	33571431	GOA
enables G protein activity	IDA IDA: Inferred from direct assay	16204467	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	34685729	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	8774883	GOA
enables adenylate cyclase regulator activity	IDA IDA: Inferred from direct assay	33762731	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15537540	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell migration	IDA IDA: Inferred from direct assay	20829352	GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	16204467	GOA
involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	33762731	GOA
involved in cell division	IMP IMP: Inferred from mutant phenotype	17635935	GOA
involved in positive regulation of cholesterol biosynthetic process	IDA IDA: Inferred from direct assay	38503280	GOA
involved in positive regulation of protein localization to cell cortex	IMP IMP: Inferred from mutant phenotype	22327364	GOA
involved in regulation of mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	23027904	GOA
involved in response to prostaglandin E	IDA IDA: Inferred from direct assay	16204467	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell cortex	IDA IDA: Inferred from direct assay	22327364	GOA
located in centrosome	IDA IDA: Inferred from direct assay	17635935	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17635935	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	17635935	GOA
part of heterotrimeric G-protein complex	IDA IDA: Inferred from direct assay	33762731	GOA
located in midbody	IDA IDA: Inferred from direct assay	17635935	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17635935	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNAI1 Protein Structure

G-alpha

0
100
200
300
354 a.a.

Protein Preferred Names	Protein Names
guanine nucleotide-binding protein G(i) subunit alpha-1	Gi1 protein alpha subunit

GNAI1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GNAI1	P63096	PCP2	Homo sapiens	Q8IVA1	Y2H Prey Pooling	32296183
Intra	GNAI1	P63096	PCP2	Homo sapiens	Q8IVA1	Validated Y2H	32296183
Intra	GNAI1	P63096	PCP2	Homo sapiens	Q8IVA1	Y2H Array	32296183
Intra	GNAI1	P63096	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	32296183
Intra	GNAI1	P63096	RGS17	Homo sapiens	Q9UGC6	Y2H Prey Pooling	25416956
Intra	GNAI1	P63096	NUMA1	Homo sapiens	Q14980	Anti Tag CoIP	15537540
Intra	GNAI1	P63096	NUMA1	Homo sapiens	Q14980	IF	15537540
Intra	GNAI1	P63096	GPSM2	Homo sapiens	P81274	Anti Tag CoIP	15537540
Intra	GNAI1	P63096	GPSM2	Homo sapiens	P81274	IF	15537540
Intra	GNAI1	P63096	RIC8A	Homo sapiens	Q9NPQ8	Anti Tag CoIP	33961781
Intra	GNAI1	P63096	RGS14	Homo sapiens	O43566	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

GNAI1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810880	GNAI1 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Hypotonia, Impaired Speech, And Behavioral Abnormalities	NEDHISB
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Pertussis	Whooping Cough Bordetella Infections Bordetella Infection Bordetella Pertussis Infection Wc - Whooping Cough Whooping Cough Due To Unspecified Organism Bordetellosis Tussis Convulsiva Whooping Cough, Unspecified Organism Wc - [Whooping Cough] Whooping Cough Due To B. Parapertussis Infection Due To Bordetella Parapertussis
Congenital Stationary Night Blindness	Night Blindness, Congenital Stationary Congenital Essential Nyctalopia Oguchi Disease Blindness, Night, Stationary, Congenital
Night Blindness	Nyctalopia
Pilomyxoid Astrocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05534	GNAI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22533	Gnai1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29053	Gnai1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GNAI1	MGD	MGI:95771
Canis familiaris	GNAI1	VGNC	VGNC:41301
Bos taurus	GNAI1	VGNC	VGNC:29449
Felis catus	GNAI1	VGNC	VGNC:62616
Rattus norvegicus	GNAI1	RGD	RGD:2713
Macaca mulatta	GNAI1	VGNC	VGNC:73089
Others	GNAI1	NCBI