Dusp3 - dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) Gene

Also Known as VHR; T-DSP11; 2210015O03Rik; 5031436O03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72349

Summary

Enables protein tyrosine/serine/threonine Phosphatase activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; and regulation of focal adhesion assembly. Acts upstream of or within protein dephosphorylation. Predicted to be located in immunological synapse and nucleoplasm. Predicted to be active in cytosol. Is expressed in central nervous system; retina; and urinary system. Orthologous to human DUSP3 (dual specificity Phosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]

Dusp3 Products (1)

mRNA Protein Name
NM_028207.3 NP_082483.1 dual specificity protein phosphatase 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphoprotein phosphatase activity IDA
IDA: Inferred from direct assay
18035061 MGI
enables protein tyrosine/serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
11432789 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to epidermal growth factor stimulus IMP
IMP: Inferred from mutant phenotype
28759036 MGI
involved in flagellated sperm motility IDA
IDA: Inferred from direct assay
37865089 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
28759036 MGI
involved in peptidyl-tyrosine dephosphorylation IMP
IMP: Inferred from mutant phenotype
28759036 MGI
involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
28759036 MGI
acts upstream of or within protein dephosphorylation IDA
IDA: Inferred from direct assay
18035061 MGI
involved in regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
28759036 MGI
Cellular Component GO Annotation Evidence References Source
is active in axonemal microtubule doublet inner sheath IDA
IDA: Inferred from direct assay
37865089 MGI
is active in sperm flagellum IDA
IDA: Inferred from direct assay
37865089 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity protein phosphatase 3

  • vaccinia H1-related phosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135457 JMS-053 Inhibitor 98.0% Unkown
HY-123846 MLS-0437605 Inhibitor 99.27% Unkown
HY-RS04064 DUSP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17699 Dusp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24161 Dusp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dusp3 NCBI NCBI:1845