Herbimycin C
Herbimycin C is a bacterial metabolite originally isolated from S. hygroscopicus. It is cytotoxic to HeLa and Ehrlich cells (IC50s=7.3 and 1.2 μg/mL, respectively).
For research use only. We do not sell to patients.
- CAS No.: 91700-92-4
- Formula: C29H40N2O9
- Molecular Weight:560.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
3.01 μM
Compound: 2
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Antiproliferative activity against human A2780 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human A2780 assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 27476419] |
| A-375 | IC50 |
2.43 μM
Compound: 2
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Antiproliferative activity against human A375 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human A375 assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 27476419] |
| BGC-823 | IC50 |
3.99 μM
Compound: 2
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Antiproliferative activity against human BGC823 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human BGC823 assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 27476419] |
| HCT-116 | IC50 |
9.39 μM
Compound: 2
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Antiproliferative activity against human HCT116 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human HCT116 assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 27476419] |
| MCF7 | IC50 |
5.07 μM
Compound: 2
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Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 27476419] |
| SW1990 | IC50 |
8.62 μM
Compound: 2
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Antiproliferative activity against human SW1990 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human SW1990 assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 27476419] |
Chemical Information
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CAS No. 91700-92-4
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Molecular Weight 560.64
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Formula C29H40N2O9
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SMILES
CO[C@@]1([H])C(C(C(NC(/C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@@H]1C)=O)=C2)=O)=CC2=O
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Synonyms
Antibiotic TAN 420D
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Herbimycin C Related Classifications
HY-126699 Related Classifications
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