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Cat. No.: HY-P10232

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Hynic-toc

Name: Hynic-toc
Brand: MedChemExpress
SKU: HY-P10232
Availability: PreOrder

(Synonyms: HYNIC-Tyr3-octreotide)

Hynic-toc (HYNIC-Tyr3-octreotide), a octreotide derivative, can be conjugated with radioactive element for tumor imaging. Hynic-toc can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

For research use only. We do not sell to patients.

CAS No.: 257943-19-4
Formula: C₅₅H₇₁N₁₃O₁₂S₂
Molecular Weight:1170.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hynic-toc Chemical Structure

CAS No.: 257943-19-4

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Use of MCE Products

One-stop CDMO Service

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity

Description

Hynic-toc (HYNIC-Tyr3-octreotide), a octreotide derivative, can be conjugated with radioactive element for tumor imaging^[1]. Hynic-toc can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

All Radionuclide-Drug Conjugates (RDCs) Isoforms :

Chemical Information

CAS No. 257943-19-4
Molecular Weight 1170.36
Formula C₅₅H₇₁N₁₃O₁₂S₂
Synonyms

HYNIC-Tyr3-octreotide
Sequence

{Hynic}-{d-Phe}-Cys-Tyr-{d-Trp}-Lys-Thr-Cys-{Thr-ol} (Disulfidebridge:Cys2-Cys7)
Sequence Shortening

{Hynic}-{d-Phe}-CY-{d-Trp}-KTC-{Thr-ol} (Disulfidebridge:Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Bioluminescent/Fluorescent Imaging Xenograft
Bioluminescent and fluorescent imaging xenograft models use tumor cells engineered to express optical reporters so tumor engraftment, growth, dissemination, and treatment response can be monitored longitudinally in living animals and validated ex vivo. Bioluminescence imaging usually measures luciferase activity after substrate administration and is commonly used as a surrogate for viable reporter-expressing tumor burden, while fluorescence imaging measures reporter or probe emission and can support tumor localization, ex vivo confirmation, or complementary multimodal analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Decristoforo C, et al. 99mTc-EDDA/HYNIC-TOC: a new 99mTc-labelled radiopharmaceutical for imaging somatostatin receptor-positive tumours; first clinical results and intra-patient comparison with 111In-labelled octreotide derivatives. Eur J Nucl Med. 2000 Sep;27(9):1318-25. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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