ACE/CD143
Angiotensin-converting enzyme (ACE, CD143) is a zinc-dependent dipeptidyl carboxypeptidase that converts angiotensin I to the vasoconstrictor angiotensin II and inactivates bradykinin, placing it centrally in blood pressure control. A somatic isoform resides on pulmonary endothelium, and a germ-cell-specific isoform arises from an alternative promoter in testis. Its two homologous extracellular domains each carry a catalytic site with distinct substrate preferences. ACE inhibitors are cornerstone antihypertensives, and ACE gene insertion-deletion polymorphisms influence enzyme levels and cardiovascular risk. Recombinant ACE is used in enzymatic assays, inhibitor testing and renin-angiotensin system research. Serum ACE activity derives from the endothelial isoform and is monitored in sarcoidosis.
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ACE/CD143 Recombinant Proteins (1)
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Inhibitors & Agonists (343)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
