MKK4/MAP2K4
MKK4, also called SEK1 or JNKK1, is encoded by MAP2K4 and belongs to the STE7 group of dual-specificity kinases. Uniquely among its relatives, it activates both the JNK and p38 branches: it phosphorylates the threonine residue within the TPY motif of JNK1/2/3 and can also act on p38 isoforms, integrating signals from TNF receptor family members, osmotic and genotoxic stress, and MAP3Ks such as the MEKK and MLK families. MKK4 influences apoptosis, embryonic liver development, and stress responses, and reduced expression or inactivating changes have been reported in several cancers, supporting a context-dependent tumor-suppressor role that distinguishes it from its paralog MKK7.
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MKK4/MAP2K4 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
