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Cat. No.: HY-W563489

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Clomoxir

Name: Clomoxir
Brand: MedChemExpress
SKU: HY-W563489
Availability: PreOrder

(Synonyms: POCA)

Clomoxir (POCA) is a carnitine palmitoyltransferase I (CPT I) inhibitor with hypoglycemic activity. Clomoxir mediates the inhibition of CPT I via its active form POCA-CoA. Clomoxir inhibits long-chain fatty acid oxidation, ketogenesis, gluconeogenesis, de novo synthesis of cholesterol and fatty acids, and also mildly inhibits acetyl-CoA carboxylase. Clomoxir reduces blood glucose levels in various rodent and porcine models, alters plasma NEFA and cholesterol concentrations, induces hepatic lipid accumulation, peroxisome proliferation and mild myocardial hypertrophy in rats, and stimulates the pentose phosphate pathway in cultured human fibroblasts. Clomoxir can be used in diabetes-related research.

For research use only. We do not sell to patients.

CAS No.: 88431-47-4
Formula: C₁₄H₁₇ClO₃
Molecular Weight:268.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Clomoxir Chemical Structure

CAS No.: 88431-47-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
- In Vivo
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Biological Activity

Description

IC₅₀ & Target^[1]

CPT-1

In Vitro

Clomoxir (POCA) exerts multiple metabolic regulatory effects: its coenzyme A ester metabolite inhibits the activity of carnitine palmitoyltransferase in rat liver mitochondria; it suppresses de novo synthesis of cholesterol and fatty acids in the liver, and blocks lactate- and pyruvate-mediated gluconeogenesis stimulated by oleic acid; it activates the pentose phosphate pathway in human fibroblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Clomoxir (POCA) (200 mg/kg; daily; 3 months) lowers blood glucose and inhibits fatty acid oxidation, ketogenesis, gluconeogenesis, and de novo lipid synthesis in multiple diabetic animal models, though high-dose chronic administration causes liver lipid accumulation, peroxisome proliferation, and mild cardiac hypertrophy in rats^[1].
Clomoxir lowers plasma NEFA and cholesterol concentrations by approximately 50% in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 88431-47-4
Molecular Weight 268.74
Formula C₁₄H₁₇ClO₃
SMILES

O=C(O)C1(OC1)CCCCCC2=CC=C(Cl)C=C2
Synonyms

POCA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Foley JE, et al. Rationale and application of fatty acid oxidation inhibitors in treatment of diabetes mellitus. Diabetes care. 1992 Jun;15(6):773-84.

[2]. Agius L, et al. Stereospecificity of the inhibition by etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochemical pharmacology. 1991 Oct 09;42(9):1717-20.

[3]. Spurway TD, et al. Etomoxir, sodium 2-[6-(4-chlorophenoxy)hexyl] oxirane-2-carboxylate, inhibits triacylglycerol depletion in hepatocytes and lipolysis in adipocytes. FEBS letters. 1997 Mar 03;404(1):111-4.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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