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Cat. No.: HY-172705

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DSPE-PEG2000-RVG29

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

DSPE-PEG2000-RVG29 is a PEG conjugate composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB), crosses the BBB, and mediates receptor-dependent transcytosis. DSPE-PEG2000-RVG29 can be used for brain-targeted drug delivery, surface modification of nanocarriers, as well as gene and nucleic acid delivery. DSPE-PEG2000-RVG29 is applicable to research related to hypoxic-ischemic brain injury, Parkinson's disease, and other conditions.

For research use only. We do not sell to patients.

Molecular Weight:2000 (Average)

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

DSPE-PEG2000-RVG29 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
- In Vivo
Chemical Information
Publications (1)
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Bioz

Biological Activity

Description

In Vitro

DSPE-PEG2000-RVG29-containing M-R@siC-NPs exhibit uniform size distribution, near-neutral surface charge, efficient siRNA loading, and long-term structural stability in biological media^[1].
DSPE-PEG2000-RVG29-containing M-R@siC-NPs (20-120 μg/mL; 24 h) show low cytotoxicity in primary astrocytes at concentrations up to 80 μg/mL, with reduced viability at higher doses^[1].
DSPE-PEG2000-RVG29-functionalized BAELPP (0.5 μg DNA equivalent per well; 24 h/48 h) achieves high transfection efficiency in SH-SY5Y human neuroblastoma cells with low cytotoxicity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

M-R@siC-NPs (containing DSPE-PEG2000-RVG29) (80 μg/mL; intraperitoneal) effectively suppress hippocampal astrocyte activation, reduce neuroinflammation, and improve motor coordination and spatial memory in HIBD neonatal mice^[1].
DSPE-PEG2000-RVG29 (10 mol%; retro-orbital injection) modification enhances brain targeting of lipopolyplexes, resulting in increased and localized transgene expression in the mouse striatum and substantia nigra^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 2000 (Average)
SMILES

[Mal-Cys-YTIWMPENPRPGTPCDIFTNSRGKRASNG]C(CCOCCOC(NCCOP(OC[C@](COC(CCCCCCCCCCCCCCCCC)=O)([H])OC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O.[n]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

J Nanobiotechnology

Apigenin regulates CCR5/JAK1/STAT1/MMPs signaling to alleviate secondary brain injury after intracerebral hemorrhage and its enhanced delivery via targeted nanoparticles. [Abstract]

2025 Nov 3;23(1):696. PMID: 41177867

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dang Y, et al. Dual-Modified Mannose/RVG29 Peptide-Functionalized Lipid Nanoparticles Loaded With circHIPK2 siRNA Ameliorate Hypoxic-Ischemic Brain Damage in Neonatal Mice by Suppressing Astrocyte Activation. J Integr Neurosci. 2025;24(12):45212. [Content Brief]

[2]. Yujing Zhang, et al. Advancing Parkinson's Prevention: Brain-Specific Lipopolyplex Delivery of Gdnf as a Neuroprotective Gene Therapy. 40 Pages Posted: 8 Jul 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

DSPE-PEG2000-RVG29

1 Cited Publications

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References

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DSPE-PEG2000-RVG29

Publications Citing Use of MedChemExpress (MCE) DSPE-PEG2000-RVG29

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

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Help & FAQs

DSPE-PEG2000-RVG29 Related Classifications

HY-172705 Related Classifications