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Pdgfrb - platelet derived growth factor receptor beta Gene

Also Known as PDGFR-1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24629

About Pdgfrb

Primary_assembly 18: 54,499,964-54,538,843 forward strand.mRatBN7.2:CM026991.1

This gene has 3 transcripts (splice variants), 247 orthologues, 54 paralogues and is associated with 59 phenotypes. Biased expression in Kidney (RPKM 224.3), Lung (RPKM 214.5) and 9 other tissues.

Summary

Enables phosphatidylinositol 3-kinase binding activity and platelet-derived growth factor-activated receptor activity. Involved in several processes, including animal organ development; positive regulation of Rho protein signal transduction; and regulation of apoptotic process. Located in several cellular components, including apical plasma membrane; cell surface; and nucleus. Used to study extrahepatic cholestasis; middle cerebral artery infarction; and prostate Cancer. Biomarker of hypertension; oligohydramnios; and sciatic neuropathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta). [provided by Alliance of Genome Resources, Apr 2022]

Pdgfrb Products (1)

mRNA	Protein	Name
NM_031525.2	NP_113713.1	platelet-derived growth factor receptor beta precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	18421086	RGD
enables platelet-derived growth factor receptor activity	IDA IDA: Inferred from direct assay	8318539	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7489253	RGD
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	16530387	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in glycosaminoglycan biosynthetic process	IMP IMP: Inferred from mutant phenotype	11903042	RGD
involved in inner ear development	IEP IEP: Inferred from expression pattern	15267171	RGD
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	18298916	RGD
involved in lung growth	IMP IMP: Inferred from mutant phenotype	8879189	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	11870082	RGD
involved in metanephric S-shaped body morphogenesis	IEP IEP: Inferred from expression pattern	10734101	RGD
involved in metanephric comma-shaped body morphogenesis	IEP IEP: Inferred from expression pattern	10734101	RGD
involved in metanephric glomerulus morphogenesis	IEP IEP: Inferred from expression pattern	10734101	RGD
involved in metanephric mesenchymal cell migration	IDA IDA: Inferred from direct assay	10734101	RGD
involved in metanephric mesenchyme development	IEP IEP: Inferred from expression pattern	10734101	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15978205	RGD
involved in positive regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	18561944	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10458478	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15267171	RGD
involved in positive regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	15978205	RGD
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	18466260	RGD
involved in positive regulation of hepatic stellate cell activation	IMP IMP: Inferred from mutant phenotype	18466260	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	15039427	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	12604637	RGD
involved in response to fluid shear stress	IEP IEP: Inferred from expression pattern	12738619	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	12226102	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	15722379	RGD
involved in response to lipid	IEP IEP: Inferred from expression pattern	15044318	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16041643	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	17303670	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	17654254	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10550325	RGD
located in cell surface	IDA IDA: Inferred from direct assay	10458478	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	10802145	RGD
located in nucleus	IDA IDA: Inferred from direct assay	11788434	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	10802145	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pdgfrb Protein Structure

PKc_like

0
200
400
600
800
1000
1097 a.a.

Protein Preferred Names	Protein Names
platelet-derived growth factor receptor beta	CD140 antigen-like family member B PDGF-R-beta PDGFR-beta Platelet-derived growth factor receptor, beta beta platelet-derived growth factor receptor beta-type platelet-derived growth factor receptor platelet derived growth factor receptor, beta polypeptide platelet-derived growth factor receptor 1

Recombinant Pdgfrb Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73360	PDGFRB Protein, Rat (HEK293, His)	Q05030 (L32-V531)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P74644	PDGFRB Protein, Rat (HEK293, Fc)	Q05030 (L32-K530)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132166	Velzatinib	Inhibitor	99.40%	Phase 3

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15813	FIIN-1	Inhibitor	99.04%	Unkown
HY-RS10257	PDGFRB Human Pre-designed siRNA Set A		/	Unkown
HY-115541	BRD4-IN-41	Inhibitor	/	Unkown
HY-RS10258	Pdgfrb Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10259	Pdgfrb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174548	Human PDGFRB mRNA		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992326	BOT1711	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdgfrb	NCBI	NCBI:5159