EGFL7 - EGF like domain multiple 7 Gene

Also Known as NEU1; ZNEU1; VE-STATIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51162

About EGFL7

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,658,856-136,672,678 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues and 5 paralogues. Broad expression in placenta (RPKM 22.8), fat (RPKM 14.4) and 19 other tissues.

Summary

This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

EGFL7 Products (2)

mRNA Protein Name
NM_016215.5 NP_057299.1 epidermal growth factor-like protein 7 precursor
NM_201446.3 NP_958854.1 epidermal growth factor-like protein 7 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21653829 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
20947685 GOA
acts upstream of or within positive regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
20947685 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EGFL7 Protein Structure

EMI

EMI: EMI domain (27 - 95)

EGF_2

EGF_2: EGF-like domain (107 - 134)

EGF_CA

EGF_CA: Calcium-binding EGF domain (137 - 176)

  • 0
  • 100
  • 200
  • 273 a.a.
Protein Preferred Names Protein Names

epidermal growth factor-like protein 7

  • EGF-like protein 7

EGFL7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EGFL7 Q9UHF1 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
EGFL7 Q9UHF1 GNE Homo sapiens Q9Y223-2
Validated Y2H
32296183
Intra
EGFL7 Q9UHF1 HOXA1 Homo sapiens P49639
Y2H Pooling
21653829
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EGFL7 Proteins

Cat. No. Product Name Accession Purity
HY-P75730 EGFL7/VE-Statin Protein, Human (sf9, His) Q9UHF1 (Y24-S273) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99215 Parsatuzumab Modulator 97.94% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04206 EGFL7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18061 Egfl7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24536 Egfl7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EGFL7 RGD RGD:708507
Macaca mulatta EGFL7 VGNC VGNC:72079
Felis catus EGFL7 VGNC VGNC:97412
Canis familiaris EGFL7 VGNC VGNC:40237
Bos taurus EGFL7 VGNC VGNC:59214
Mus musculus EGFL7 MGD MGI:2449923
Others EGFL7 NCBI