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RNF146 - ring finger protein 146 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81847

About RNF146

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:127,266,682-127,288,562 (from NCBI)

This gene has 13 transcripts (splice variants) and 276 orthologues. Ubiquitous expression in fat (RPKM 18.0), lung (RPKM 11.1) and 25 other tissues.

Summary

Enables poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RNF146 Products (10)

mRNA	Protein	Name
NM_001242844.2	NP_001229773.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242845.2	NP_001229774.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242846.2	NP_001229775.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242847.2	NP_001229776.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242848.2	NP_001229777.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242849.2	NP_001229778.1	E3 ubiquitin-protein ligase RNF146 isoform b
NM_001242850.2	NP_001229779.1	E3 ubiquitin-protein ligase RNF146 isoform b
NM_001242851.1	NP_001229780.1	E3 ubiquitin-protein ligase RNF146 isoform b
NM_001242852.2	NP_001229781.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_030963.4	NP_112225.2	E3 ubiquitin-protein ligase RNF146 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables poly-ADP-D-ribose binding	IDA IDA: Inferred from direct assay	21478859	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21478859	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	21478859	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	21478859	GOA
involved in protein K48-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	21478859	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	21478859	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	21478859	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	15813938	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF146 Protein Structure

zf-C3HC4

WWE

0
100
200
300
359 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF146	RING-type E3 ubiquitin transferase RNF146

RNF146 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF146	Q9NTX7	TUBGCP4	Homo sapiens	Q9UGJ1	Y2H Prey Pooling	25416956
Intra	RNF146	Q9NTX7	TUBGCP4	Homo sapiens	Q9UGJ1	Y2H Array	25416956
Intra	RNF146	Q9NTX7	TNKS	Homo sapiens	O95271	Pull Down	25327252
Intra	RNF146	Q9NTX7	TNKS	Homo sapiens	O95271	Anti Tag CoIP	21799911
Intra	RNF146	Q9NTX7	TNKS	Homo sapiens	O95271	Anti Tag CoIP	25327252
Intra	RNF146	Q9NTX7	TNKS	Homo sapiens	O95271	GMS	25327252
Intra	RNF146	Q9NTX7	TNKS	Homo sapiens	O95271	Light Scattering	25327252
Intra	RNF146	Q9NTX7	PARP1	Homo sapiens	P09874	Anti Tag CoIP	21799911
Intra	RNF146	Q9NTX7	PARP1	Homo sapiens	P09874	Pull Down	21799911
Intra	RNF146	Q9NTX7	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	RNF146	Q9NTX7	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	RNF146	Q9NTX7	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

RNF146 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83471	RNF14 Antibody (YA3216)	WB	Human, Mouse, Rat
HY-P83471A	RNF14 Antibody (YA3216)(PBS only)	WB	Human, Mouse, Rat
HY-P87053	RNF146 Antibody (YA6746)	WB, IHC-P, ICC/IF, FC	Human, Mouse

Related Diseases

Diseases	Alias
Cherubism	CRBM Familial Benign Giant-Cell Tumor Of The Jaw Familial Fibrous Dysplasia Of Jaw Familial Multilocular Cystic Disease Of The Jaws
Arthrogryposis, Renal Dysfunction, And Cholestasis 1	Arc Syndrome ARCS1 Arthrogryposis Renal Dysfunction Cholestasis Syndrome Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome Arcs Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, And Cholestasis Arthrogryposis-Renal Dysfunction-Cholestasis Arthrogryposis - Renal Dysfunction - Cholestasis Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1 Arthrogryposis Renal Dysfunction And Cholestasis 1 Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1 Kidney Failure Renal Insufficiency
Alcohol-Related Birth Defects	Arbd Alcohol-Related Birth Defect Alcohol Related Birth Defect Fetal Alcohol Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12056	RNF146 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20592	Rnf146 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27100	Rnf146 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNF146	RGD	RGD:1306482
Canis familiaris	RNF146	VGNC	VGNC:45638
Mus musculus	RNF146	MGD	MGI:1915281
Felis catus	RNF146	VGNC	VGNC:64675
Macaca mulatta	RNF146	VGNC	VGNC:76798
Others	RNF146	NCBI