CARTPT - CART prepropeptide Gene

Also Known as CART

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9607

About CARTPT

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:71,719,275-71,721,045 (from NCBI)

This gene has 2 transcripts (splice variants), 270 orthologues and is associated with 1 phenotype. Biased expression in adrenal (RPKM 51.3), brain (RPKM 5.7) and 1 other tissue.

Summary

This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016]

CARTPT Products (1)

mRNA Protein Name
NM_004291.4 NP_004282.1 cocaine- and amphetamine-regulated transcript protein preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular glucose homeostasis IDA
IDA: Inferred from direct assay
11711504 GOA
involved in negative regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
16614075 GOA
involved in positive regulation of blood pressure IDA
IDA: Inferred from direct assay
11711504 GOA
involved in positive regulation of epinephrine secretion IDA
IDA: Inferred from direct assay
11711504 GOA
involved in positive regulation of transmission of nerve impulse IDA
IDA: Inferred from direct assay
11711504 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11711504 GOA
located in secretory granule IDA
IDA: Inferred from direct assay
21624661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARTPT Protein Structure

CART

CART: Cocaine and amphetamine regulated transcript protein (CART) (45 - 116)

  • 0
  • 100
  • 116 a.a.
Protein Preferred Names Protein Names

cocaine- and amphetamine-regulated transcript protein

CARTPT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CARTPT Q16568 CEACAM1 Homo sapiens P13688
Protein Array
21982860
Intra
CARTPT Q16568 CEACAM6 Homo sapiens P40199
SPR
21982860
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CARTPT Proteins

Cat. No. Product Name Accession Purity
HY-P74350 CART Protein, Human (HEK293, Fc) Q16568 (Q28-L116) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74351 CART Protein, Human (HEK293) Q16568/NP_004282.1 (Q28-L116) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Leptin Deficiency Or Dysfunction

  • Morbid Obesity

  • Obesity Due To Congenital Leptin Deficiency

  • LEPD

  • Congenital Leptin Deficiency

  • Obesity, Morbid

  • Obesity, Morbid, Due To Leptin Deficiency

  • Severe Obesity

  • Obesity, Morbid, Nonsyndromic 1

  • Leptin Deficiency

  • Obesity, Severe, Due To Leptin Deficiency

  • Leptin

  • Morbid Obesity Due To Leptin Deficiency

  • Obesity Morbid

  • Leptin Dysfunction
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Diabetes Mellitus

  • Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01935 CARTPT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21831 Cartpt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28348 Cartpt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CARTPT VGNC VGNC:60375
Macaca mulatta CARTPT VGNC VGNC:70619
Rattus norvegicus CARTPT RGD RGD:2272
Mus musculus CARTPT MGD MGI:1351330
Bos taurus CARTPT VGNC VGNC:26774
Canis familiaris CARTPT VGNC VGNC:38727
Others CARTPT NCBI