DMTAP
Based on 1 Customer Validation
DMTAP is a cationic lipid that can be used for delivery of DNA, RNAi and drugs.
For research use only. We do not sell to patients.
- Purity : 99.67%
- CAS No.: 197974-74-6
- Formula: C34H68ClNO4
- Molecular Weight:590.36
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
![Trimethyl[2,3-(dioleyloxy)propyl]ammonium chloride](https://file.medchemexpress.com/product_pic/hy-w127644.gif)
Biological Activity
Description
Chemical Information
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CAS No. 197974-74-6
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Appearance Solid
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Molecular Weight 590.36
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Formula C34H68ClNO4
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Color White to off-white
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SMILES
CCCCCCCCCCCCCC(OCC(OC(CCCCCCCCCCCCC)=O)C[N+](C)(C)C)=O.[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
Ethanol : 20 mg/mL (33.88 mM; Need ultrasonic)
DMSO : 2 mg/mL (3.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Gurtovenko AA, et al. Cationic DMPC/DMTAP lipid bilayers: molecular dynamics study. Biophys J. 2004 Jun;86(6):3461-72. [Content Brief]
[2]. Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811. [Content Brief]
[3]. Lajunen T, et al. Topical drug delivery to retinal pigment epithelium with microfluidizer produced small liposomes. Eur J Pharm Sci. 2014 Oct 1;62:23-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 1.6939 mL | 8.4694 mL | 16.9388 mL | 42.3470 mL |
| Ethanol | 5 mM | 0.3388 mL | 1.6939 mL | 3.3878 mL | 8.4694 mL |
| 10 mM | 0.1694 mL | 0.8469 mL | 1.6939 mL | 4.2347 mL | |
| 15 mM | 0.1129 mL | 0.5646 mL | 1.1293 mL | 2.8231 mL | |
| 20 mM | 0.0847 mL | 0.4235 mL | 0.8469 mL | 2.1174 mL | |
| 25 mM | 0.0678 mL | 0.3388 mL | 0.6776 mL | 1.6939 mL | |
| 30 mM | 0.0565 mL | 0.2823 mL | 0.5646 mL | 1.4116 mL |
DMTAP Related Classifications
HY-112523A Related Classifications
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