DOPE-PEG2000-DHLASLWWGTEL

DOPE-PEG2000-DHLASLWWGTEL: surface functionalization of liposomes and nanoparticles for tissue-targeted drug delivery, enabling selective drug accumulation in specific tissues identified through phage display screening.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes pH-responsive membrane fusion for intracellular cargo release;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces opsonization and immune clearance, and extends circulation half-life;
(3) DHLASLWWGTEL peptide; a 12-residue tissue-targeting peptide identified by phage display that specifically recognizes and binds to receptors or surface markers on target tissue cells, directing nanocarriers to specific tissues for enhanced drug accumulation and therapeutic efficacy while minimizing off-target effects.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.