1. PROTAC
  2. Ligand for E3 Ligase
  3. E3 ligase Ligand 8

E3 ligase Ligand 8 

Cat. No.: HY-43961 Purity: 98.84%
Handling Instructions

E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

For research use only. We do not sell to patients.

E3 ligase Ligand 8 Chemical Structure

E3 ligase Ligand 8 Chemical Structure

CAS No. : 1225383-33-4

Size Price Stock Quantity
50 mg USD 290 In-stock
Estimated Time of Arrival: December 31
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1850 In-stock
Estimated Time of Arrival: December 31
1 g USD 3350 In-stock
Estimated Time of Arrival: December 31
2 g USD 4900 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

Molecular Weight

530.61

Formula

C₃₁H₃₄N₂O₆

CAS No.

1225383-33-4

SMILES

CC(C)C[[email protected]@H](C(O)=O)NC([[email protected]@H](O)[[email protected]](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CC4=CC=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (188.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8846 mL 9.4231 mL 18.8462 mL
5 mM 0.3769 mL 1.8846 mL 3.7692 mL
10 mM 0.1885 mL 0.9423 mL 1.8846 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

E3 ligase Ligand 8Ligand for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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Product Name:
E3 ligase Ligand 8
Cat. No.:
HY-43961
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