EGFR-IN-140
EGFR-IN-140 (Compound 31) is the inhibitor for EGFR, that inhibits EGFR wildtype and EGFR L858R/T790M/C797S mutant with Ki of 0.95 nM and 2.1 nM, and inhibits EGFR del19/T790M/C797S in Ba/F3 with an IC50 of 56.9 nM. EGFR-IN-140 exhibits antitumor efficacy in mouse model.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C27H37FN8O2
- Molecular Weight:524.63
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
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EGFR 0.95 nM (Ki) |
EGFRL858R/T790M/C797S 2.1 nM (Ki) |
Chemical Information
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Molecular Weight 524.63
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Formel C27H37FN8O2
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SMILES
CN(CC[C@@]12CC[C@H](N3C4=CC(NC5=NC(N6CC[C@@H](OC)[C@@H](F)C6)=NC=C5)=NN4C=C3CC)CC2)C1=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
EGFR-IN-140 Related Classifications
HY-170497 Related Classifications
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