2. Apoptosis
  3. Apoptosis
  4. ERK-IN-6

ERK-IN-6 (compound 6g) is an potent anti-proliferation agent against esophageal squamous cell carcinoma (ESCC). ERK-IN-6 induces cell apoptosis via ERK pathway. ERK-IN-6 can be used for the research of ESCC.

For research use only. We do not sell to patients.

ERK-IN-6 Chemical Structure

ERK-IN-6 Chemical Structure

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ERK-IN-6 Related Antibodies

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Description

ERK-IN-6 (compound 6g) is an potent anti-proliferation agent against esophageal squamous cell carcinoma (ESCC). ERK-IN-6 induces cell apoptosis via ERK pathway. ERK-IN-6 can be used for the research of ESCC[1].

IC50 & Target

IC50: 16.8 µM (KYSE-30), 10.07 µM (KYSE-150), 13 µM (HET-1A), 202.2 µM (NES-G4T)[1]
In Vitro

ERK-IN-6 (0-10 µM; 72 h) inhibits cell proliferation of ESCC cells[1].
ERK-IN-6 (10 µM; 48-72 h) induces cell apoptosis through the ERK pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ERK-IN-6 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: KYSE-30, KYSE-150, HET-1A and NES-G4T cell lines
Concentration: 0-10 µM
Incubation Time: 72 hours
Result: Dose-dependently inhibited cell proliferation of KYSE-30, KYSE-150, HET-1A and NES-G4T cells with IC50 values of 16.8, 10.07, 13 and 202.2 µM, respectively.

Apoptosis Analysis[1]

Cell Line: KYSE-30 and KYSE-150 cell lines
Concentration: 10 µM
Incubation Time: 48 and 72 hours
Result: Induced KYSE-30 and KYSE-150 cell apoptosis with the loss of nuclei integrity at 72 h.

Western Blot Analysis[1]

Cell Line: KYSE-150 and NES-G4T cell lines
Concentration: 10 µM
Incubation Time: 4, 8 and 12 hours
Result: Time-dependently down regulated pERK.
Molecular Weight

448.33

Formula

C19H18BrN3O3S
SMILES

CC1(C)N/C(S/C1=C\C2=CC=C(Br)C=C2)=N/C3=CC=C(OC)C=C3[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ERK-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERK-IN-6ApoptosisthiazolidineESCCcell proliferationapoptosisERK pathwayInhibitorinhibitorinhibit

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ERK-IN-6
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HY-151934
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