ERK-IN-6
ERK-IN-6 (compound 6g) is an potent anti-proliferation agent against esophageal squamous cell carcinoma (ESCC). ERK-IN-6 induces cell apoptosis via ERK pathway. ERK-IN-6 can be used for the research of ESCC.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C19H18BrN3O3S
- Masse moléculaire:448.33
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: 16.8 µM (KYSE-30), 10.07 µM (KYSE-150), 13 µM (HET-1A), 202.2 µM (NES-G4T)[1]
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HET-1A | IC50 |
13 μM
Compound: 6g
|
Antiproliferative activity against human HET-1A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HET-1A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 36508971] |
| KYSE-150 cell line | IC50 |
10.07 μM
Compound: 6g
|
Antiproliferative activity against human KYSE-150 cell line assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human KYSE-150 cell line assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 36508971] |
| KYSE-30 | IC50 |
16.8 μM
Compound: 6g
|
Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 36508971] |
In Vitro
ERK-IN-6 (0-10 µM; 72 h) inhibits cell proliferation of ESCC cells[1]. ERK-IN-6 (10 µM; 48-72 h) induces cell apoptosis through the ERK pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:KYSE-30, KYSE-150, HET-1A and NES-G4T cell lines
-
Concentration:0-10 µM
-
Incubation Time:72 hours
-
Result:Dose-dependently inhibited cell proliferation of KYSE-30, KYSE-150, HET-1A and NES-G4T cells with IC50 values of 16.8, 10.07, 13 and 202.2 µM, respectively.
-
Cell Line:KYSE-30 and KYSE-150 cell lines
-
Concentration:10 µM
-
Incubation Time:48 and 72 hours
-
Result:Induced KYSE-30 and KYSE-150 cell apoptosis with the loss of nuclei integrity at 72 h.
-
Cell Line:KYSE-150 and NES-G4T cell lines
-
Concentration:10 µM
-
Incubation Time:4, 8 and 12 hours
-
Result:Time-dependently down regulated pERK.
Chemical Information
-
Masse moléculaire 448.33
-
Formule C19H18BrN3O3S
-
SMILES
CC1(C)N/C(S/C1=C\C2=CC=C(Br)C=C2)=N/C3=CC=C(OC)C=C3[N+]([O-])=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ERK-IN-6 Related Classifications
HY-151934 Related Classifications
Powered by Bioz