Ass1 - argininosuccinate synthase 1 Gene

Also Known as Ass; ASSA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25698

Summary

Enables argininosuccinate synthase activity and toxic substance binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and cellular response to organonitrogen compound. Located in several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Biomarker of uveitis. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ass1 Products (1)

mRNA Protein Name
NM_013157.4 NP_037289.1 argininosuccinate synthase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables argininosuccinate synthase activity IDA
IDA: Inferred from direct assay
4062872 RGD
enables argininosuccinate synthase activity IMP
IMP: Inferred from mutant phenotype
19491403 RGD
enables toxic substance binding IPI
IPI: Inferred from physical interaction
11083085 RGD
Biological Process GO Annotation Evidence References Source
involved in L-arginine biosynthetic process IDA
IDA: Inferred from direct assay
12470967 RGD
involved in L-arginine biosynthetic process IMP
IMP: Inferred from mutant phenotype
19491403 RGD
involved in acute-phase response IEP
IEP: Inferred from expression pattern
15698416 RGD
involved in argininosuccinate metabolic process IDA
IDA: Inferred from direct assay
4062872 RGD
involved in cellular response to amine stimulus IEP
IEP: Inferred from expression pattern
18457831 RGD
involved in cellular response to amino acid stimulus IEP
IEP: Inferred from expression pattern
9893939 RGD
involved in cellular response to ammonium ion IEP
IEP: Inferred from expression pattern
10353334 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
8923475 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
9395312 RGD
involved in cellular response to glucagon stimulus IEP
IEP: Inferred from expression pattern
9395312 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
9879717 RGD
involved in cellular response to oleic acid IEP
IEP: Inferred from expression pattern
8985169 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
11072090 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
11072090 RGD
involved in diaphragm development IEP
IEP: Inferred from expression pattern
9618389 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
10473900 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
9395312 RGD
involved in midgut development IEP
IEP: Inferred from expression pattern
9544996 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
16168957 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
17938381 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16339744 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
19651254 RGD
involved in response to glucocorticoid IDA
IDA: Inferred from direct assay
8923475 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
9688877 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
12589771 RGD
involved in response to mycotoxin IDA
IDA: Inferred from direct assay
11083085 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
15257170 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
9688877 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
9688877 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
20452409 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
9252090 RGD
involved in response to zinc ion IDA
IDA: Inferred from direct assay
11686784 RGD
involved in urea cycle IDA
IDA: Inferred from direct assay
4062872 RGD
involved in urea cycle IMP
IMP: Inferred from mutant phenotype
19491403 RGD
Cellular Component GO Annotation Evidence References Source
located in cell body fiber IDA
IDA: Inferred from direct assay
12445581 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
8867809 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12445581 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
17900569 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

argininosuccinate synthase

  • argininosuccinate synthetase 1

  • arginosuccinate synthetase 1

  • citrulline--aspartate ligase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156112 LM2I Activator 99.78% Unkown
HY-RS01109 ASS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181832 ASS1 activator 1 / Unkown
HY-RS17217 Ass1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23669 Ass1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992098 Adargiminase / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ass1 NCBI NCBI:445