ATAT1 - alpha tubulin acetyltransferase 1 Gene

Also Known as TAT; MEC17; C6orf134; Nbla00487; alpha-TAT; alpha-TAT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79969

About ATAT1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,626,874-30,646,821 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele and 191 orthologues. Ubiquitous expression in brain (RPKM 7.7), testis (RPKM 3.5) and 23 other tissues.

Summary

This gene encodes a protein that localizes to clathrin-coated pits, where it acetylates alpha tubulin on lysine 40. This process may be important in microtubule growth, for instance during chemotaxis and the formation of cilium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

ATAT1 Products (7)

mRNA Protein Name
NM_001031722.4 NP_001026892.1 alpha-tubulin N-acetyltransferase 1 isoform 1 precursor
NM_001190724.4 NP_001177653.1 alpha-tubulin N-acetyltransferase 1 isoform 3 precursor
NM_001254952.4 NP_001241881.1 alpha-tubulin N-acetyltransferase 1 isoform 4
NM_001318762.3 NP_001305691.1 alpha-tubulin N-acetyltransferase 1 isoform 5
NM_001318763.3 NP_001305692.1 alpha-tubulin N-acetyltransferase 1 isoform 6
NM_001413067.1 NP_001399996.1 alpha-tubulin N-acetyltransferase 1 isoform 7
NM_024909.5 NP_079185.2 alpha-tubulin N-acetyltransferase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor EXP
EXP: Inferred from Experiment
23071318 GOA
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
IDA: Inferred from direct assay
24906155 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
36931259 GOA
enables tubulin N-acetyltransferase activity IDA
IDA: Inferred from direct assay
23071314 GOA
enables tubulin N-acetyltransferase activity IMP
IMP: Inferred from mutant phenotype
20829795 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within alpha-tubulin acetylation IDA
IDA: Inferred from direct assay
23071314 GOA
involved in alpha-tubulin acetylation IDA
IDA: Inferred from direct assay
24906155 GOA
Cellular Component GO Annotation Evidence References Source
located in mitotic spindle IDA
IDA: Inferred from direct assay
23720746 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATAT1 Protein Structure

Acetyltransf_16

Acetyltransf_16: GNAT acetyltransferase, Mec-17 (72 - 192)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 421 a.a.
Protein Preferred Names Protein Names

alpha-tubulin N-acetyltransferase 1

  • acetyltransferase mec-17 homolog

ATAT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATAT1 Q5SQI0 YWHAE Homo sapiens P62258
Crosslink
36931259
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spherocytosis, Type 1

  • Hereditary Spherocytosis Type 1

  • SPH1

  • Hs1

  • Spherocytosis, Hereditary, 1

  • Sph

  • Hs

  • Hereditary Spherocytosis 1

  • Spherocytosis 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01124 ATAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19656 Atat1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26149 Atat1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ATAT1 MGD MGI:1913869
Felis catus ATAT1 VGNC VGNC:59992
Canis familiaris ATAT1 VGNC VGNC:38204
Rattus norvegicus ATAT1 RGD RGD:1303066
Bos taurus ATAT1 VGNC VGNC:26236
Macaca mulatta ATAT1 VGNC VGNC:70106
Others ATAT1 NCBI