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Cat. No.: HY-158741

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IPG-2 AM

Name: IPG-2 AM
Brand: MedChemExpress
SKU: HY-158741
Price: 1500.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: APG-2 Acetoxymethyl ester)

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IPG-2 AM (APG-2 Acetoxymethyl ester) is a membrane-permeant acetoxymethyl ester derivative and selective fluorescent potassium ion indicator. IPG-2 AM exhibits fluorescence increases proportional to extracellular potassium ion concentrations. IPG-2 AM enables real-time monitoring of cytosolic free potassium ion fluxes in human platelets and macrophages. IPG-2 AM can be used for the research of intracellular potassium concentration dynamics.

For research use only. We do not sell to patients.

Purity: 94.00%
CAS No.: 1369302-24-8
Formula: C₅₅H₆₄Cl₂N₂O₁₉
Molecular Weight:1128.00

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

IPG-2 AM Chemical Structure

CAS No.: 1369302-24-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

IPG-2 AM (1 μM; 10 min at 37°C) enables quantitative detection of intracellular potassium concentration changes in J774A.1 macrophages and BMDMs exposed to nsPEFs, and can detect immediate potassium efflux and subsequent recovery processes in most treated cell populations^[1].
Real-time flow cytometry analysis monitors cytoplasmic potassium efflux in human platelets treated with IPG-2 AM (0.1 μM; 60 min)^[2].
IPG-2 AM (0.1 μM; 60 min) exhibits an apparent K_d of 31 mM in human platelets, which validates its suitability for the quantitative detection of cytoplasmic potassium concentrations^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1369302-24-8
Appearance Solid
Molecular Weight 1128.00
Formula C₅₅H₆₄Cl₂N₂O₁₉
SMILES

O=C(C)OCOC(CCC1=CC2=C(C3=CC(OC)=C(N4CCOCCOCCN(CCOCCOCC4)C5=CC=C(C)C=C5OC)C=C3)C6=C(C(Cl)=C(C(CCC(OCOC(C)=O)=O)=C6)OCOC(C)=O)OC2=C(C1=O)Cl)=O
Synonyms

APG-2 Acetoxymethyl ester
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mazzarda F, et al. Inflammasome activation and IL-1β release triggered by nanosecond pulsed electric fields in murine innate immune cells and skin. The Journal of Immunology. 2024 Jan;212(2):335-45.

[2]. Aliotta A, et al. Flow Cytometric Monitoring of Dynamic Cytosolic Calcium, Sodium, and Potassium Fluxes Following Platelet Activation. Cytometry A. 2020;97(9):933-944. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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