Keracyanin chloride
Based on 1 publication(s) in Google Scholar
Keracyanin chloride inhibits NF-κB/FAK/MAPK signaling pathway. Keracyanin chloride exhibits antioxidant, anti-inflammatory and hypoglycemic effects, and is orally active.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 18719-76-1
- Formula: C27H31ClO15
- Molecular Weight:630.98
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Keracyanin chloride
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Biological Activity
Keracyanin chloride (0.8 μM, 48 h) suppresses the phosphorylation level of NF-κB p65, inhibits the protein expression of PPAR-γ in THP-1 cell, downregulates the inflammation-related gene expression of TNF-α, IL-1β, IL-6 and MCP-1[3].
Keracyanin chloride (10-200 µM, 24 h) inhibits blue light-induced ROS generation in HaCaT cell, inhibits FAK/MAPK/ERK/JNK signaling pathway, thereby exhibiting anti-inflammatory effect[4].
Keracyanin chloride exhibits a weak inhibitory activity against intestinal α-glucosidase (IC50s for maltase and sucrase are 2323 μM and 250.2 μM), delays carbohydrate digestion and absorption, and exhibits hypoglycemic effect[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1
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Concentration:0.8 μM
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Incubation Time:48 h
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Result:Inhibited the PPAR-γ expression and phosphorylation of NF-κB p65.
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Cell Line:THP-1
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Concentration:0.8 μM
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Incubation Time:48 h
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Result:Downregulated the mRNA expression levels of TNF-α, IL-1β, IL-6 and MCP-1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats models[5]
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Dosage:30-300 mg/kg
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Administration:po, single dose
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Result:Inhibited the increase in blood glucose after oral administration of maltose and sucrose.
Chemical Information
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CAS No. 18719-76-1
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Appearance Solid
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Molecular Weight 630.98
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Formula C27H31ClO15
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Color Brown to reddish brown
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SMILES
OC1=C2C([O+]=C(C3=CC(O)=C(O)C=C3)C(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO[C@H]5[C@@H]([C@@H]([C@@H](O)[C@H](C)O5)O)O)=C2)=CC(O)=C1.[Cl-]
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Synonyms
Cyanidin 3-rutinoside chloride; Cyanidin 3-O-rutinoside chloride; Sambucin chloride
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 Oct 15:489:144992. PMID: 40466530
Solvent & Solubility
DMSO : 25 mg/mL (39.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Mazzaracchio P, et al. Interaction between gliadins and anthocyan derivatives. Food Chem. 2011 Dec 1;129(3):1100-7. [Content Brief]
[2]. Matsufuji H, et al. Inhibition of malonaldehyde formation in oxidized calf thymus DNA with synthetic and natural antioxidants. J Agric Food Chem. 2004 Sep 8;52(18):5759-63. [Content Brief]
[3]. Santamarina AB , et al., Anti-inflammatory effects of oleic acid and the anthocyanin keracyanin alone and in combination: effects on monocyte and macrophage responses and the NF-κB pathway. Food Funct. 2021 Sep 7;12(17):7909-7922. [Content Brief]
[5]. Adisakwattana S, et al., Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal α-glucosidase. J Clin Biochem Nutr. 2011 Jul;49(1):36-41. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5848 mL | 7.9242 mL | 15.8484 mL | 39.6209 mL |
| 5 mM | 0.3170 mL | 1.5848 mL | 3.1697 mL | 7.9242 mL | |
| 10 mM | 0.1585 mL | 0.7924 mL | 1.5848 mL | 3.9621 mL | |
| 15 mM | 0.1057 mL | 0.5283 mL | 1.0566 mL | 2.6414 mL | |
| 20 mM | 0.0792 mL | 0.3962 mL | 0.7924 mL | 1.9810 mL | |
| 25 mM | 0.0634 mL | 0.3170 mL | 0.6339 mL | 1.5848 mL | |
| 30 mM | 0.0528 mL | 0.2641 mL | 0.5283 mL | 1.3207 mL |
Keracyanin chloride Related Classifications
HY-105935 Related Classifications
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