HDAC-IN-93
HDAC-IN-93 is a HDAC inhibitor with promising total pan-HDAC inhibitory activity. HDAC-IN-93 demonstrates significant broad-spectrum antiproliferative activity across various cancer cell lines. HDAC-IN-93 induces cell apoptosis along with necrosis. HDAC-IN-93 can be used for the studies of prostate cancer and breast cancer.
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- Fòrmula: C18H14N2O3
- Peso molecular:306.32
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas Caspase
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Actividad biológica
|
HDAC6 |
HDAC7 |
HDAC8 |
Bax |
Caspase 3 |
Bcl-2 |
HDAC-IN-93 (Compound 17) is sensitive to a variety of cancer cell lines, with particularly significant effects on prostate cancer PC-3 cells and breast cancer MCF-7 cells with IC50 values of 4.1 μM and 20.8 μM, respectively[1].
HDAC-IN-93 (4.1 μM, 24 h) causes a significant increase in the number of cells in the SubG0-G1 phase, and induces early apoptosis in MCF-7 cells[1].
HDAC-IN-93 (4.1 μM, 24 h) upregulates pro-apoptotic genes (Bax, Cyt-C, Caspase-3) and downregulates anti-apoptotic genes (Bcl-2) in MCF-7 cells[1].
HDAC-IN-93 (4.1 μM, 24 h) shows total HDAC inhibitory activity of 66.1 % at MCF-7 although shows relatively weak direct inhibitory activity against specific HDAC subtypes (6, 7, 8)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:4.1 μM
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Incubation Time:24 h
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Result:Significant increased the subG0-G1 phase cell population (21.5%).
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Cell Line:MCF-7 cells
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Concentration:4.1 μM
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Incubation Time:24 h
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Result:Induced early apoptosis.
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Cell Line:MCF-7 cells
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Concentration:4.1 μM
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Incubation Time:24 h
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Result:Upregulated Bax, Cyt-C and Caspase-3 and downregulated the Bcl-2.
Chemical Information
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Peso molecular 306.32
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Fòrmula C18H14N2O3
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SMILES
N/C(C(C=C1)=CC=C1/C=C/C2=CC(C3=CC=CC=C3O2)=O)=N\O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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