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United States

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Referencia número: HY-161716

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LH1753

LH1753 is an orally active L-cystine crystallization inhibitor with an EC₅₀ of 29.5 nM. LH1753 can be used for Cystinuria research.

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No. CAS: 2650492-10-5
Fòrmula: C₂₂H₄₄Cl₄N₆O₂S₂
Peso molecular:630.57

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

LH1753 Chemical Structure

No. CAS: 2650492-10-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

LH1753 is an orally active L-cystine crystallization inhibitor with an EC₅₀ of 29.5 nM. LH1753 can be used for Cystinuria research^[1].

In Vivo

LH1753 (150 μmol/kg, i.g., QD for 8 weeks) inhibits the L-cystine stone formation and has no effect on the growth of Slc3a1-knockout mouse model of cystinuria^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2650492-10-5
Peso molecular 630.57
Fòrmula C₂₂H₄₄Cl₄N₆O₂S₂
SMILES

O=C([C@@H](N)CSSC[C@H](N)C(N1CCC2(NCCC2)CC1)=O)N3CCC4(NCCC4)CC3.Cl.Cl.Cl.Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Longqin Hu, et al. 8-l-Cystinyl Bis(1,8-diazaspiro[4.5]decane) as an Orally Bioavailable l-Cystine Crystallization Inhibitor for Cystinuria, ACS Medicinal Chemistry Letters, Article ASAP

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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