2. GPCR/G Protein
  3. LPL Receptor
  4. Ex26

Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach.

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Ex26

Ex26 構造式

CAS 番号 : 1233332-37-0

容量 価格（税別） 在庫状況 数量
5 mg $344 在庫あり
10 mg $550 在庫あり
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Ex26 関連抗体

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LPL Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

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製品説明

Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach[1].

IC50 & Target

IC50: 0.93 nM (S1P1)[1]
体外実験

Ex26 (0-10 μM; 1 h) treatment shows excellent selectivity for S1P1 over other Sphingosine 1-phosphate receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ex26 関連抗体

Cell Viability Assay[1]

Cell Line: U2OS cells, and Chinese hamster ovary cells
Concentration: 0-10 μM
Incubation Time: 1 hour
Result: Confirmed a potent and selective antagonist of S1P1 (IC50=0.93 nM).
体内実験

Ex26 (i.p.; 3 mg/kg; once daily; 3 d) treatment disrupts S1P1 signaling inhibiting the lymphocyte and thymocyte egress[1].
Ex26 (i.p.; 30 mg/kg; once daily; 15 d) treatment alleviates experimental autoimmune encephalomyelitis by S1P1 antagonism[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male C57Bl/6J mice[1]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection; 3 mg/kg; once daily; 3 days
Result: Induced lymphocyte sequestration at low doses, possessing an ED50 of 0.06 mg/kg after 2 hours treatment. Led to significant retention of T and B cells within the lymph nodes and significant decreases in T and B cells within the spleen.
Animal Model: Eight-week-old male C57Bl/6J mice induced with experimental autoimmune encephalomyelitis[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; 30 mg/kg; once daily; 15 days
Result: Inhibited both lymphocyte infiltration and destruction of the white matter in the spinal cord of mice euthanized at the end of the experiment.
分子量

494.98

分子式

C28H28ClFN2O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1(CC1)NC(C2=C(C=C(C=C2C)C3=CC(NC(C)C4=CC=C(C(C)=C4)Cl)=CC=C3F)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
純度とドキュメンテーション

純度: 99.4%

COA (245 KB) Elemental Analysis Report (103 KB)

取扱説明書 (2659 KB)
参考文献
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Ex26 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ex261233332-37-0S1P1-IN-Ex26Ex 26Ex-26LPL ReceptorLysophospholipid Receptorexperimental autoimmune encephalomyelitisEAEU2OSChinese hamster ovary cellsInhibitorinhibitorinhibit

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製品番号:
HY-117213
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