2. Immunology/Inflammation
  3. FAP
  4. FAP Ligand 3

FAP Ligand 3 (compound 54) is a reagent that binds to FAP, with a Ki value of 0.092 nM against human targets. FAP Ligand 3 acts as a tumor-retaining agent and serves as a FAP-targeted positron emission tomography (PET) tracer for tumor imaging. FAP Ligand 3 is applicable to studies related to U87MG glioma.

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FAP Ligand 3

FAP Ligand 3 Chemical Structure

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FAP Ligand 3 Related Antibodies

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Description

FAP Ligand 3 (compound 54) is a reagent that binds to FAP, with a Ki value of 0.092 nM against human targets. FAP Ligand 3 acts as a tumor-retaining agent and serves as a FAP-targeted positron emission tomography (PET) tracer for tumor imaging. FAP Ligand 3 is applicable to studies related to U87MG glioma[1].

In Vitro

FAP Ligand 3 (compound 54) (10-6 to 10-12 M; 60 min) potently inhibits recombinant human FAP with a Ki value of 0.092 nM[1].
FAP Ligand 3 (~120 μCi) has a log D7.4 value of 0.47, indicating low lipophilicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FAP Ligand 3 Related Antibodies
In Vivo

[18F]FAP Ligand 3 (compound 54) (~100 μCi; intravenous; single dose) demonstrates sustained FAP-specific tumor retention in U87MG tumor-bearing mice, achieving a peak tumor-to-muscle ratio of 11 at 30 minutes postinjection with only 19% tumor uptake reduction over 90 minutes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (n=3)[1]
Dosage: ~100 μCi
Administration: intravenous; single dose
Result: Achieved a tumor SUVmean of 1.6 and a tumor-to-muscle ratio (TMR) of 11 at 30 minutes postinjection.
Decreased tumor uptake only 19% by 120 minutes postinjection, with an SUVmean of 1.3, and maintained a TMR of 9.8-11 throughout the imaging window.
Improved tumor-to-liver ratio to 3.9 by 120 minutes postinjection.
Significantly reduced tumor uptake when coinjected with FAPI-04, confirming FAP-specific binding.
Molecular Weight

748.75

Formula

C34H43F3N8O8
SMILES

O=C(C1=CC=NC2=CC=C(C=C21)OCCOCCOCCNC(CCC3=CN(N=N3)CCOCCOCCF)=O)NCC(N4[C@@H](CC(F)(C4)F)C#N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FAP Ligand 3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAP Ligand 3FAP Ligand3FAP Ligand-3FAPFibroblast activation proteintumor imagingtumor retention agentpositron emission tomographyPETU87MG gliomaCuAACrecombinant human FAPmouse plasmaU87MG tumor-bearing miceInhibitorinhibitorinhibit

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