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Cat. No.: HY-181580

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FAP Ligand 3

FAP Ligand 3 is a FAP ligand with a K_i value of 0.092 nM. FAP Ligand 3 acts as a tumor-retaining agent and serves as a FAP-targeted positron emission tomography (PET) tracer for tumor imaging. FAP Ligand 3 is applicable to studies related to glioma.

For research use only. We do not sell to patients.

Formula: C₃₄H₄₃F₃N₈O₈
Molecular Weight:748.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

FAP Ligand 3 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

[¹⁸F]FAP Ligand 3 (compound 54) (~100 μCi; intravenous; single dose) demonstrates sustained FAP-specific tumor retention in U87MG tumor-bearing mice, achieving a peak tumor-to-muscle ratio of 11 at 30 minutes postinjection with only 19% tumor uptake reduction over 90 minutes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude mice^[1]
Dosage:

~100 μCi
Administration:

intravenous; single dose
Result:

Achieved a tumor SUVmean of 1.6 and a tumor-to-muscle ratio (TMR) of 11 at 30 minutes postinjection.
Decreased tumor uptake only 19% by 120 minutes postinjection, with an SUVmean of 1.3, and maintained a TMR of 9.8-11 throughout the imaging window.
Improved tumor-to-liver ratio to 3.9 by 120 minutes postinjection.
Significantly reduced tumor uptake when coinjected with FAPI-04, confirming FAP-specific binding.

Chemical Information

Molecular Weight 748.75
Formula C₃₄H₄₃F₃N₈O₈
SMILES

O=C(C1=CC=NC2=CC=C(C=C21)OCCOCCOCCNC(CCC3=CN(N=N3)CCOCCOCCF)=O)NCC(N4[C@@H](CC(F)(C4)F)C#N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gao X, et al. Exploring Covalent C-¹⁸F Bonding Strategies in the Design of FAP-Targeted Radiotracers. J Med Chem. 2026;69(3):2938-2953. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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