FAP Ligand 3
FAP Ligand 3 is a FAP ligand with a Ki value of 0.092 nM. FAP Ligand 3 acts as a tumor-retaining agent and serves as a FAP-targeted positron emission tomography (PET) tracer for tumor imaging. FAP Ligand 3 is applicable to studies related to glioma.
For research use only. We do not sell to patients.
- Formula: C34H43F3N8O8
- Molecular Weight:748.75
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c nude mice[1]
-
Dosage:~100 μCi
-
Administration:intravenous; single dose
-
Result:Achieved a tumor SUVmean of 1.6 and a tumor-to-muscle ratio (TMR) of 11 at 30 minutes postinjection.
Decreased tumor uptake only 19% by 120 minutes postinjection, with an SUVmean of 1.3, and maintained a TMR of 9.8-11 throughout the imaging window.
Improved tumor-to-liver ratio to 3.9 by 120 minutes postinjection.
Significantly reduced tumor uptake when coinjected with FAPI-04, confirming FAP-specific binding.
Chemical Information
-
Molecular Weight 748.75
-
Formula C34H43F3N8O8
-
SMILES
O=C(C1=CC=NC2=CC=C(C=C21)OCCOCCOCCNC(CCC3=CN(N=N3)CCOCCOCCF)=O)NCC(N4[C@@H](CC(F)(C4)F)C#N)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Bioluminescent/Fluorescent Imaging Xenograft
Bioluminescent and fluorescent imaging xenograft models use tumor cells engineered to express optical reporters so tumor engraftment, growth, dissemination, and treatment response can be monitored longitudinally in living animals and validated ex vivo. Bioluminescence imaging usually measures luciferase activity after substrate administration and is commonly used as a surrogate for viable reporter-expressing tumor burden, while fluorescence imaging measures reporter or probe emission and can support tumor localization, ex vivo confirmation, or complementary multimodal analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FAP Ligand 3 Related Classifications
HY-181580 Related Classifications
Powered by Bioz