2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR-IN-1

FGFR-IN-1 is a potent FGFR inhibitor with an IC50 of <100 nM for FGFR1, FGFR2, and FGFR3, respectively (patent US20130338134A1, example 219).

For research use only. We do not sell to patients.

FGFR-IN-1 Chemical Structure

FGFR-IN-1 Chemical Structure

CAS No. : 1513860-41-7

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5 mg USD 1050 In-stock
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Based on 1 publication(s) in Google Scholar

FGFR-IN-1 Related Antibodies

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

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Description

FGFR-IN-1 is a potent FGFR inhibitor with an IC50 of <100 nM for FGFR1, FGFR2, and FGFR3, respectively (patent US20130338134A1, example 219)[1].

Molecular Weight

558.55

Formula

C26H24F2N4O6S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N(CC2=CN=C3C(C=C(CO)N3S(=O)(C4=CC=CC=C4)=O)=C2N1CC)C5=C(F)C(OC)=CC(OC)=C5F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (89.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7903 mL 8.9517 mL 17.9035 mL
5 mM 0.3581 mL 1.7904 mL 3.5807 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7904 mL 8.9518 mL 17.9035 mL 44.7588 mL
5 mM 0.3581 mL 1.7904 mL 3.5807 mL 8.9518 mL
10 mM 0.1790 mL 0.8952 mL 1.7904 mL 4.4759 mL
15 mM 0.1194 mL 0.5968 mL 1.1936 mL 2.9839 mL
20 mM 0.0895 mL 0.4476 mL 0.8952 mL 2.2379 mL
25 mM 0.0716 mL 0.3581 mL 0.7161 mL 1.7904 mL
30 mM 0.0597 mL 0.2984 mL 0.5968 mL 1.4920 mL
40 mM 0.0448 mL 0.2238 mL 0.4476 mL 1.1190 mL
50 mM 0.0358 mL 0.1790 mL 0.3581 mL 0.8952 mL
60 mM 0.0298 mL 0.1492 mL 0.2984 mL 0.7460 mL
80 mM 0.0224 mL 0.1119 mL 0.2238 mL 0.5595 mL
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FGFR-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR-IN-11513860-41-7FGFRFibroblast growth factor receptorInhibitorinhibitorinhibit

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