FtsZ-IN-16

FtsZ-IN-16 (B01) (48 h) potently inhibits the growth of Xanthomonas oryzae pv. oryzae (Xoo), with an MIC of 8 μg/mL and an EC₅₀ of 3.74 μg/mL^[1].
FtsZ-IN-16 (4.0 μg/mL; 24 h) induces cell elongation and inhibits bacterial cell division in Xanthomonas oryzae pv. oryzae^[1].
FtsZ-IN-16 binds to wild-type Xanthomonas oryzae pv. oryzae FtsZ protein with a K_d value of 43.63 μM, among which the LEU71, GLY74, GLY110 and THR111 residues are essential for high-affinity binding^[1].
FtsZ-IN-16 (100-200 μM; 10 min preincubation, 20 min GTP incubation) inhibits the FtsZ GTPase activity of wild-type Xanthomonas oryzae pv. oryzae in a concentration-dependent manner, with an inhibition rate of 25.69% at 200 μM. Moreover, the LEU71, GLY74, GLY110 and THR111 residues are critical for this activity^[1].
FtsZ-IN-16 (50-100 μM; 20 min total) inhibits FtsZ polymerization of wild-type Xanthomonas oryzae pv. oryzae in a concentration-dependent manner, where the Leu71, Gly74, Gly110 and Thr111 residues are critical for this activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.