2. Cell Cycle/DNA Damage
  3. IRE1
  4. G6374

G6374 is an IRE1 PROTAC degrader with a DC50 of 0.04 μM. G6374 induces efficient ubiquitination and degradation of IRE1. G6374 selectively inhibits IRE1-dependent cancer-cell proliferation.
(Pink: Ligands for Target Protein for PROTAC and IRE1 ligand (HY-180780); Blue: Ligands for E3 Ligase and VHL ligand (HY-125845); Black: linker (HY-W041652)).

For research use only. We do not sell to patients.

G6374

G6374 Chemical Structure

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G6374 Related Antibodies

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Description

G6374 is an IRE1 PROTAC degrader with a DC50 of 0.04 μM. G6374 induces efficient ubiquitination and degradation of IRE1. G6374 selectively inhibits IRE1-dependent cancer-cell proliferation[1]. (Pink: Ligands for Target Protein for PROTAC and IRE1 ligand (HY-180780); Blue: Ligands for E3 Ligase and VHL ligand (HY-125845); Black: linker (HY-W041652)).

IC50 & Target

DC50: 0.04 μM (IRE1)[1]
Molecular Weight

883.16

Formula

C47H66N10O5S
SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCN4CCN(CC4)[C@H]5CC[C@@H](CC5)NC6=NC7=C(C=N6)C=CC(N7C(C)C)=O)=O)=O)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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G6374 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G6374G 6374G-6374IRE1Inositol requiring enzyme 1PROTACcancerInhibitorinhibitorinhibit

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HY-180787
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