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United States

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Art. -Nr.: HY-180787

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G6374

G6374 is an IRE1 PROTAC degrader with a DC₅₀ of 0.04 μM. G6374 induces efficient ubiquitination and degradation of IRE1. G6374 selectively inhibits IRE1-dependent cancer-cell proliferation.
(Pink: Ligands for Target Protein for PROTAC and IRE1 ligand (HY-180780); Blue: Ligands for E3 Ligase and VHL ligand (HY-125845); Black: linker (HY-W041652)).

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Formel: C₄₇H₆₆N₁₀O₅S
Molecular Weight:883.16

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

G6374 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

G6374 is an IRE1 PROTAC degrader with a DC₅₀ of 0.04 μM. G6374 induces efficient ubiquitination and degradation of IRE1. G6374 selectively inhibits IRE1-dependent cancer-cell proliferation^[1]. (Pink: Ligands for Target Protein for PROTAC and IRE1 ligand (HY-180780); Blue: Ligands for E3 Ligase and VHL ligand (HY-125845); Black: linker (HY-W041652)).

IC₅₀ & Target

DC₅₀: 0.04 μM (IRE1)^[1]

Chemical Information

Molecular Weight 883.16
Formel C₄₇H₆₆N₁₀O₅S
SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCN4CCN(CC4)[C@H]5CC[C@@H](CC5)NC6=NC7=C(C=N6)C=CC(N7C(C)C)=O)=O)=O)O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Du J, et al. Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera. Nat Commun. 2025 Dec 11;16(1):11445. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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