GABAA receptor agent 6
GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with an Ki of 0.56 µM. GABAA receptor agent 6 shows γ-GABAAR antagonist activity with low cellular membrane permeability.
For research use only. We do not sell to patients.
- CAS No.: 1808463-81-1
- Formula: C18H25N3O2
- Molecular Weight:315.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
Ki: 0.56 µM (γ-GABAAR)[1]
In Vitro
GABAA receptor agent 6 (compound 2027) shows antagonist activity with IC50s of 6.68, 1.03, 0.36, 4.13, 4.96, 2.96, 0.29, 0.59 µM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1808463-81-1
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Molecular Weight 315.41
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Formula C18H25N3O2
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SMILES
O=C(C)NC1=CC=CC(C(N2CCC3(CC2)CCNCC3)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Transepithelial/transendothelial electrical resistance assay
TEER measures electrical resistance across epithelial or endothelial monolayers cultured on permeable supports, and the readout reflects ionic conductance through the cell barrier, especially the paracellular pathway regulated by junctional integrity. TEER can be measured without destroying the monolayer and is commonly used before or during transport, permeability, barrier-disruption, and barrier-maturation experiments. TEER values are influenced by biological maturation and technical conditions; reported factors include temperature, medium formulation, passage number, electrode geometry, membrane properties, and junctional length during early monolayer maturation. Therefore, TEER should be interpreted with blank-insert subtraction, area normalization, repeated readings, and, when possible, orthogonal barrier readouts such as FITC-dextran flux or tight-junction staining.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GABAA receptor agent 6 Related Classifications
HY-145258 Related Classifications
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Keywords
- GABAA receptor agent 6
- 1808463-81-1
- GABAA receptor agent6
- GABAA receptor agent-6
- GABA Receptor
- GABAA receptor agent 6 (compound 2027) shows antagonist activity with IC50s of 6.68
- 1.03
- 0.36
- 4.13
- 4.96
- 2.96
- 0.29
- 0.59 μM for α1β2δ
- α4β1δ
- α4β2δ
- α6β2δ
- α1β2γ2
- α2β2γ2
- α3β2γ2
- α5β2γ2 subtypes
- respectively[1].
- Inhibitor
- inhibitor
- inhibit