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Ceralasertib

(Synonyms: AZD6738)
68 Cited Publications
Revisión del cliente

Based on 68 publication(s) in Google Scholar

Ceralasertib (AZD6738) is an orally active and bioavailable inhibitor of ATR kinase with an IC50 of 1 nM.

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  • Pureza: 99.43%
  • No. CAS: 1352226-88-0
  • Fòrmula: C20H24N6O2S
  • Peso molecular:412.51
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Ceralasertib Chemical Structure
    Ceralasertib Chemical Structure
  • Experimental Validation Results for Ceralasertib
  • Experimental Validation Results for Ceralasertib
  • Experimental Validation Results for Ceralasertib
  • Experimental Validation Results for Ceralasertib
  • Experimental Validation Results for Ceralasertib
No. CAS: 1352226-88-0
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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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  • Ceralasertib Chemical Structure
    Ceralasertib Chemical Structure
    1/16
  • 1/16

    Ceralasertib purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 16;15(1):1446. [Abstract]

    Customer Validation
     Immunoblot of KPC cells harboring doxycycline-inducible shRNA targeting luciferase, components of the PAF1c and MYC. Depletion was induced by doxycycline addition for 72 h and AZD6738 treatment for 72 h at 0.2 µM concentration. * refers to a non-specific band. Beta-actin was loading control (n=3).

  • 1/16

    Ceralasertib purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 16;15(1):1446. [Abstract]

    Customer Validation
     pKAP1(S824) intensity upon incubation with AZD6738 (0.1 µM; 24 h) (number of KPC cells plotted: siNTC: n=1654; siCDC73:n=1175).Scale bar: 10 µm. siRNA transfection was 48 h and EdU was added 30 minutes before fixation.

  • 1/16

    Ceralasertib purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2024 Jan 11;52(1):204-222. [Abstract]

    Customer Validation
     AZD6738 (1 μM) were administered for 30 minutes prior to UV irradiation (20 J/m2). HeLa cells were allowed to recover for 2 h after UV treatment, and phosphorylation of DHX9, Chk1, Chk2, and RPA32 was assessed by Western blot with indicated antibodies.

  • 1/16

    Ceralasertib purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Aug 4;13(1):4520. [Abstract]

    Customer Validation
     ATR inhibitor AZD6738 prevent NCI‐H929 TP53−/− cell growth in NSG mice. NSG mice were subcutaneously injected with 106 NCI‐H929 TP53−/− cells (left panel). After 1 week, mice with detectable tumors were randomly distributed into four groups of seven mice and treated with AZD6738 (25 mg/kg; i.g., 5 times a week for 2 weeks), as indicated by the arrows (middle panel). The graphs represent the tumor volume kinetics (mean±SD, middle panel) and the tumor volume on Day 12 (right panel).

  • 1/16

    Ceralasertib purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Nov 16;41(1):323. [Abstract]

    Customer Validation
     Ceralasertib (AZD6738; 1, 2 µM) signifcantly decreases the protein levels of ATR, IFI16 and HuR in a dose-dependent manner in GSC 267 and GSC 20 cells.

  • Ceralasertib