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Ceralasertib formate

(Synonyms: AZD-6738 formate)
68 Cited Publications
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Based on 68 publication(s) in Google Scholar

Ceralasertib formate is a potent, selective and orally active ATR inhibitor with an IC50 value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity.

For research use only. We do not sell to patients.

  • CAS No.: 1352280-98-8
  • Formula: C20H24N6O2S.xCH2O2
  • Molecular Weight:458.53
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Ceralasertib formate Chemical Structure
    Ceralasertib formate Chemical Structure
  • Experimental Validation Results for Ceralasertib formate
  • Experimental Validation Results for Ceralasertib formate
  • Experimental Validation Results for Ceralasertib formate
  • Experimental Validation Results for Ceralasertib formate
  • Experimental Validation Results for Ceralasertib formate
CAS No.: 1352280-98-8
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  • Ceralasertib formate Chemical Structure
    Ceralasertib formate Chemical Structure
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    Ceralasertib formate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 16;15(1):1446. [Abstract]

    Customer Validation
     Immunoblot of KPC cells harboring doxycycline-inducible shRNA targeting luciferase, components of the PAF1c and MYC. Depletion was induced by doxycycline addition for 72 h and AZD6738 treatment for 72 h at 0.2 µM concentration. * refers to a non-specific band. Beta-actin was loading control (n=3).

  • 1/16

    Ceralasertib formate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 16;15(1):1446. [Abstract]

    Customer Validation
     pKAP1(S824) intensity upon incubation with AZD6738 (0.1 µM; 24 h) (number of KPC cells plotted: siNTC: n=1654; siCDC73:n=1175).Scale bar: 10 µm. siRNA transfection was 48 h and EdU was added 30 minutes before fixation.

  • 1/16

    Ceralasertib formate purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2024 Jan 11;52(1):204-222. [Abstract]

    Customer Validation
     AZD6738 (1 μM) were administered for 30 minutes prior to UV irradiation (20 J/m2). HeLa cells were allowed to recover for 2 h after UV treatment, and phosphorylation of DHX9, Chk1, Chk2, and RPA32 was assessed by Western blot with indicated antibodies.

  • 1/16

    Ceralasertib formate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Aug 4;13(1):4520. [Abstract]

    Customer Validation
     ATR inhibitor AZD6738 prevent NCI‐H929 TP53−/− cell growth in NSG mice. NSG mice were subcutaneously injected with 106 NCI‐H929 TP53−/− cells (left panel). After 1 week, mice with detectable tumors were randomly distributed into four groups of seven mice and treated with AZD6738 (25 mg/kg; i.g., 5 times a week for 2 weeks), as indicated by the arrows (middle panel). The graphs represent the tumor volume kinetics (mean±SD, middle panel) and the tumor volume on Day 12 (right panel).

  • 1/16

    Ceralasertib formate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Nov 16;41(1):323. [Abstract]

    Customer Validation
     Ceralasertib (AZD6738; 1, 2 µM) signifcantly decreases the protein levels of ATR, IFI16 and HuR in a dose-dependent manner in GSC 267 and GSC 20 cells.

  • Ceralasertib formate