2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. Ceralasertib formate

Ceralasertib formate is a potent, selective and orally active ATR inhibitor with an IC50 value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity.

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CAS No. : 1352280-98-8

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Ceralasertib formate Related Antibodies

Top Publications Citing Use of Products

60 Publications Citing Use of MCE Ceralasertib formate

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    Ceralasertib formate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 16;15(1):1446.  [Abstract]

    Immunoblot of KPC cells harboring doxycycline-inducible shRNA targeting luciferase, components of the PAF1c and MYC. Depletion was induced by doxycycline addition for 72 h and AZD6738 treatment for 72 h at 0.2 µM concentration. * refers to a non-specific band. Beta-actin was loading control (n=3).

    Ceralasertib formate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 16;15(1):1446.  [Abstract]

    pKAP1(S824) intensity upon incubation with AZD6738 (0.1 µM; 24 h) (number of KPC cells plotted: siNTC: n=1654; siCDC73:n=1175).Scale bar: 10 µm. siRNA transfection was 48 h and EdU was added 30 minutes before fixation.

    Ceralasertib formate purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2024 Jan 11;52(1):204-222.  [Abstract]

    AZD6738 (1 μM) were administered for 30 minutes prior to UV irradiation (20 J/m2). HeLa cells were allowed to recover for 2 h after UV treatment, and phosphorylation of DHX9, Chk1, Chk2, and RPA32 was assessed by Western blot with indicated antibodies.

    Ceralasertib formate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Aug 4;13(1):4520.  [Abstract]

    ATR inhibitor AZD6738 prevent NCI‐H929 TP53−/− cell growth in NSG mice. NSG mice were subcutaneously injected with 106 NCI‐H929 TP53−/− cells (left panel). After 1 week, mice with detectable tumors were randomly distributed into four groups of seven mice and treated with AZD6738 (25 mg/kg; i.g., 5 times a week for 2 weeks), as indicated by the arrows (middle panel). The graphs represent the tumor volume kinetics (mean±SD, middle panel) and the tumor volume on Day 12 (right panel).

    Ceralasertib formate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Nov 16;41(1):323.  [Abstract]

    Ceralasertib (AZD6738; 1, 2 µM) signifcantly decreases the protein levels of ATR, IFI16 and HuR in a dose-dependent manner in GSC 267 and GSC 20 cells.

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    Description

    Ceralasertib formate is a potent, selective and orally active ATR inhibitor with an IC50 value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity[1][2].

    In Vitro

    Ceralasertib formate (0, 0.3, 1 μM; 48 h) induces cell senescence in A549 cells in a dose-dependent manner[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ceralasertib formate Related Antibodies
    Molecular Weight

    458.53

    Formula

    C20H24N6O2S.xCH2O2
    CAS No.
    SMILES

    C[C@H]1N(CCOC1)C2=CC(C3(CC3)[S@@](=N)(C)=O)=NC(C4=C5C(NC=C5)=NC=C4)=N2.OC=O.[F,Cl,Br,I]
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    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Ceralasertib formate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ceralasertib formate1352280-98-8AZD-6738 formateATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedorally activeDNA damagesenescenceantitumorNSCLCA549 cellsInhibitorinhibitorinhibit

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