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Referencia número: HY-U00313

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Tropodifene

(Synonyms: Tropaphen)

Tropodifene (Tropaphen) is an α-Adrenergic receptor inhibitor.

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No. CAS: 15790-02-0
Fòrmula: C₂₅H₂₉NO₄
Peso molecular:407.50

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Tropodifene Chemical Structure

No. CAS: 15790-02-0

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vivo
Chemical Information
Protocolo
Pureza y Documentación
Referencias
Calculators
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Bioz

Actividad biológica

Descripciòn

Tropodifene (Tropaphen) is an α-Adrenergic receptor inhibitor.

IC₅₀ & Target

α-Adrenergic^[1]

Ver todos los productos específicos de isoformas Adrenergic Receptor :

In Vivo

Tropaphen has a beneficial effect on hypertension. The therapeutic effect of this preparation is more constant in diseases accompanied by spasm of the peripheral vessels. Tropaphen has a very marked adrenolytic and vasodilator action. It greatly lowers the tone of the peripheral vessels. The preparation is effective starting with a dose of 0.1 mg/kg. After injection of the drug in a dose of 0.25 mg/kg, a considerable and gradually progressive decrease in the perfusion pressure takes place. The pressure falls by 30-35% and remained at a low level for 90-100 min. With a dose of tropaphen of 0.5 mg/kg, the perfusion pressure falls by 40-45% and remains low for 120 min or more. Strong vasodilatation is also observed after injection of tropaphen into intact rabbits^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 15790-02-0
Peso molecular 407.50
Fòrmula C₂₅H₂₉NO₄
SMILES

O=C(O[C@H]1C[C@H](N2C)CC[C@H]2C1)C(C3=CC=CC=C3)CC4=CC=C(OC(C)=O)C=C4
Synonyms

Tropaphen
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocolo

Animal Administration^[1]

Rabbits^[1]

The drug is injected intravenously into rabbits. Experiments on the isolated ears of the rabbits are carried out by the Kravkov--Pisemskii method. The effect of tropaphen on the ear vessels of the intact rabbit is judged by the changes in the temperature of the ear. The temperature is measured by means of an electrothermometer, the detector of which is fixed to the internal surface of the ear. The dilation of the auricular vessels is also examined under the microscope, observations being made on the lumen of the marginal artery and vein^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Mashkovskii MD, et al. The action of tropaphen on the peripheral vessels. Pharmacology. 1964. 58. 69-71.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Tropodifene

Ver todos los productos específicos de isoformas Adrenergic Receptor